N-bromosuccinimide promoted synthesis of β-amino bromides under Appel reaction condition

被引：0

作者：

Chinthaginjala, Srinivasulu ^{[1
]}

Alavandimat, Nanda H. ^{[1
]}

Umesha, Vathsala ^{[1
]}

Sureshbabu, Vommina V. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Chem, Peptide Res Lab, Bengaluru, India

来源：

SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 19期

关键词：

N-bromosuccinimide; N-beta-protected amino alcohols; N-beta-protected amino bromides; ALKYL CHLORIDES; MEDICINAL CHEMISTRY; CARBOXYLIC-ACIDS; ALCOHOLS; CONVERSION; WITTIG; CARBON; STEREOCHEMISTRY; TRANSFORMATION; HALOGENATION;

D O I：

10.1080/00397911.2021.1955270

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and facile method has been developed for the synthesis of chiral beta-amino bromides from their corresponding alcohols under Appel reaction conditions. This approach allows for the deoxybromination of a variety of beta-amino alcohols in excellent yields under mild conditions without any detectable racemization.

引用

页码：2975 / 2983

页数：9

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