Microwave Method for the Synthesis of Amantadine Hydrochloride

被引：0
|
作者：
Thinh Van Nguyen [1 ]
Hien Van Pham [1 ]
Duong Binh Vu [1 ]
Anh Tuan Dang [2 ]
Vu Khac Tran [2 ]
Chau Dinh Phan [2 ]
机构：
[1] Hanoi Univ Sci & Technol, Vietnam Mil Med Univ, Hanoi, Vietnam
[2] Hanoi Univ Sci & Technol, Sch Chem Engn, Hanoi, Vietnam
来源：
CHIANG MAI JOURNAL OF SCIENCE | 2018年 / 45卷 / 06期
关键词：
amantadine hydrochloride; adamantane; acetonitrile; N-(1-adamantyl)acetamide; microwave radiation; Parkinson's disease; GRIGNARD-REAGENTS; PRIMARY AMINES; ELECTROPHILIC AMINATION; O-SULFONYLOXIME;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An easy and rapid method to prepare amantadine hydrochloride (1), which was used for the treatment of certain influenza infections type A and Parkinson's disease was developed. In this work, we report a microwave method, which was effective in heating and saving solvents, for the synthesis of amantadine hydrochloride from adamantane by Ritter-type reaction via N-(1-adamantyl)acetamide in a two-step procedure with an improved overall yield 71%. The reaction conditions were investigated to increase the overall yield and to shorten the reaction time, reduce the use of toxic reagents, solvents, rendering it more effective and environment-friendly
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页码：2454 / 2458
页数：5
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