Contribution of molecular chiral mesoporous silica nanoparticles in delivering drugs with chiral recognition ability

Among massive study of mesoporous silica nanoparticles, molecular chiral mesoporous silica nanoparticles (MC-MSN) enjoy great interests recently as it may exert special functions in chiral environment. To elucidate its potential abilities as drug carriers, the present work focused on its prominent advantage of chiral recognition in adsorbing and delivering drug molecules, which mainly covered molecular recognition of racemic drugs and chiral delivery of achiral drug by triggering chiral responses in biological environment. The result turned out that the loading capacity of L-alanine was 1.56-fold higher than that of DL-alanine, reminding that MC-MSN had effective molecular recognition function due to its chirality. Furthermore, the peak area ratio of levorotary ofloxacin/dextral ofloxacin from loaded ofloxacin was obviously higher than ofloxacin, confirming that MC-MSN can molecularly recognize levorotary drug. After loading poorly water-soluble drug indometacin (IMC) into MC-MSN, the carrier delivered IMC with improved anti-inflammation effect based on its chiral recognition effect.