Rhodium-Catalyzed Asymmetric 1,4-Addition of Sodium Tetraarylborates to β,β-Disubstituted α,β-Unsaturated Esters

被引：64

作者：

Shintani, Ryo ^{[1
]}

Hayashi, Tamio ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 02期

关键词：

QUATERNARY STEREOGENIC CENTERS; 5-(1-ARYLALKYLIDENE) MELDRUMS ACIDS; CONJUGATE ADDITION; ENANTIOSELECTIVE SYNTHESIS; TRISUBSTITUTED ENONES; DIALKYLZINC REAGENTS; GRIGNARD-REAGENTS; ARYLZINC REAGENTS; ARYLBORONIC ACIDS; CARBON CENTERS;

D O I：

10.1021/ol102674z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rhodium-catalyzed 1,4-addition of sodium tetraarylborates to beta,beta-disubstituted alpha,beta-unsaturated esters has been developed. Highly efficient asymmetric catalysis has also been described to create quaternary carbon stereocenters at the beta-position of esters by tuning the ester group of substrates and employing a readily available chiral diene ligand.

引用

页码：350 / 352

页数：3

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