Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides

被引：27
|
作者：
Yang, Bing-You [1 ]
Zhang, Jing [1 ]
Liu, Yan [1 ]
Kuang, Hai-Xue [1 ]
机构：
[1] Heilongjiang Univ Chinese Med, Key Lab Chinese Mat Med, Minist Educ, Harbin 150040, Peoples R China
来源：
MOLECULES | 2016年 / 21卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Asparagaceae; furostanol saponin; spirostanol saponin; MTT; cytotoxicity; TIMOSAPONIN B-II; INDUCED APOPTOSIS;
D O I：
10.3390/molecules21081075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four new steroid saponins 1-4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC50 values of 43.90 and 57.90 mu M, respectively.
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页数：9
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