Evidence that the reward attenuating effect of the D1-like antagonist, SCH-23390, is not mediated by its agonist action at the 5-HT2c receptors

被引：5
|
作者：
Benaliouad, Faiza [1 ]
Zhornitsky, Simon [2 ]
Rompre, Pierre-Paul [2 ,3 ]
机构：
[1] Univ Montreal, Dept Physiol, Montreal, PQ H1N 3V2, Canada
[2] Univ Montreal, Dept Psychiat, Montreal, PQ H1N 3V2, Canada
[3] Concordia Univ, FRSQ Res Grp Behav Neurobiol, Montreal, PQ H4B 1R6, Canada
来源：
BEHAVIOURAL BRAIN RESEARCH | 2011年 / 217卷 / 02期
关键词：
Dopamine; Reward; Serotonin; SB-242,084; SCH-23390; SELF-STIMULATION THRESHOLDS; VENTRAL TEGMENTAL AREA; BRAIN-STIMULATION; NUCLEUS-ACCUMBENS; IN-VIVO; SEROTONIN(2C) RECEPTORS; CONSTITUTIVE ACTIVITY; DOPAMINE; DRUGS; BLOCKADE;
D O I：
10.1016/j.bbr.2010.09.023
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
This study investigated the effect of the 5-HT2c receptor antagonist, SB-242,084, on the attenuation of brain stimulation reward by SCH-23390. An additional experiment determined the effectiveness of SB-242,084 at blocking the reward attenuating effect of 5-HT2c agonist, CP-809,101. Results show that SB-242,084 blocked the reward attenuating effect of CP-809,101 but failed to alter that of SCH-23390. These findings provide evidence that the agonist action of SCH-23390 at the 5-HT2c receptors does not contribute to its attenuating effect on reward. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：467 / 471
页数：5
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