Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion

被引：71
|
作者：
Zhao, Xiaoxuan [1 ]
Jiang, Yuepeng [1 ]
Wang, Lin [1 ]
Li, Zhihao [1 ]
Li, Qiang [1 ]
Feng, Xiaoling [2 ]
机构：
[1] Heilongjiang Univ Chinese Med, Harbin 150040, Heilongjiang, Peoples R China
[2] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Harbin 150040, Heilongjiang, Peoples R China
来源：
GEBURTSHILFE UND FRAUENHEILKUNDE | 2018年 / 78卷 / 07期
关键词：
Th17; cells; Treg cells; decidual natural killer cells; recurrent spontaneous abortion; review; NATURAL-KILLER-CELLS; MATERNAL-FETAL INTERFACE; TH17; CELLS; PERIPHERAL-BLOOD; EARLY-PREGNANCY; FETOMATERNAL TOLERANCE; ADOPTIVE TRANSFER; REGULATORY CELLS; MENSTRUAL-CYCLE; RECEPTORS;
D O I：
10.1055/a-0634-1813
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Recurrent spontaneous abortion is a global problem, and unexplained recurrent abortion triggered by immunological factors is an important focus of current research. Helper T lymphocytes (Th cells) and regulatory T lymphocytes (Treg cells) are central in human immune regulation and play a complex role in pregnancy. Natural killer cells (NK cells) exist in the endometrium and cooperate with T lymphocytes to create immune tolerance at the maternal-fetal interface, which is essential for successful pregnancy. This review has analyzed studies on Th17 cell, Treg cell and NK cell dysfunction and cellular imbalances which may contribute to unexplained recurrent spontaneous abortion to suggest a possible direction for future immunotherapies.
引用
收藏
页码：677 / 683
页数：7
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