Interactions of Cr(VI) and Cr(III) with isolated rat liver mitochondria

被引：3
|
作者：
Iero, Alessandra [2 ]
Manente, Sabrina [1 ]
De Pieri, Silvia [1 ]
Mane, Eranda [1 ]
Gallo, Michele [1 ]
Cima, Francesca [3 ]
Ballarin, Loriano [3 ]
Bragadin, Marcantonio [1 ]
机构：
[1] Ca Foscari Univ Venice, Dept Environm Sci, I-30123 Venice, Italy
[2] Univ Canberra, Inst Appl Ecol Hlth Sci & Design, Bruce, ACT, Australia
[3] Univ Padua, Dept Biol, I-35121 Padua, Italy
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2010年 / 13卷 / 05期
关键词：
Chromium; Mitochondria; Apoptosis; MPT; PERMEABILITY TRANSITION PORE; HEXAVALENT CHROMIUM; CYTOCHROME-C; APOPTOSIS; REDUCTION; MECHANISM; TRANSPORT; RELEASE; PATHWAY; CARRIER;
D O I：
10.1016/j.inoche.2010.03.017
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The mechanism of interaction of Cr(VI) with isolated rat liver mitochondria was investigated in this study. The results suggest that Cr(VI) induces the opening of the membrane permeability transition pore (MPT). The phenomenon is cyclosporine-sensitive and is in agreement with the cyclosporine-sensitive apoptosis observed in the cells incubated with this compound. Moreover the action of Cr(III), that is formed in the cells by a reduction of Cr(VI), has been also analysed. The results obtained demonstrated that the Cr(III) does not induce the opening of the MPT in isolated mitochondria, but it has a protective effect in preventing Cr(VI) MPT opening. Therefore, these results suggest that apoptosis is regulated by a balance between Cr(VI) accumulation in the cytoplasm and Cr(III) formation. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：676 / 678
页数：3
相关论文
共 50 条
  • [31] Supported liquid membrane system for Cr(III) separation from Cr(III)/Cr(VI) mixtures
    Religa, P.
    Rajewski, J.
    Gierycz, P.
    Swietlik, R.
    WATER SCIENCE AND TECHNOLOGY, 2014, 69 (12) : 2476 - 2481
  • [32] Adsorption of Cr(VI) and Speciation of Cr(VI) and Cr(III) in Aqueous Solutions Using Chemically Modified Chitosan
    Dai, Jun
    Ren, FengLian
    Tao, ChunYuan
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2012, 9 (05) : 1757 - 1770
  • [33] Cr(VI) reduction by bacteria species isolated from Cr(VI) polluted landfill
    Tsigaridas, Kostas
    Sawidis, Thomas
    Sivropoulou, Afroditi
    CURRENT OPINION IN BIOTECHNOLOGY, 2011, 22 : S57 - S57
  • [34] Assessing the phytotoxicity of chromium in Cr(VI)-spiked soils by Cr speciation using XANES and resin extractable Cr(III) and Cr(VI)
    Chiou-Pin Chen
    Kai-Wei Juang
    Tzu-Huei Lin
    Dar-Yuan Lee
    Plant and Soil, 2010, 334 : 299 - 309
  • [35] Assessing the phytotoxicity of chromium in Cr(VI)-spiked soils by Cr speciation using XANES and resin extractable Cr(III) and Cr(VI)
    Chen, Chiou-Pin
    Juang, Kai-Wei
    Lin, Tzu-Huei
    Lee, Dar-Yuan
    PLANT AND SOIL, 2010, 334 (1-2) : 299 - 309
  • [36] POLAROGRAPHIC STUDIES OF CATALYTIC REDUCTION OF HYDROGEN IN CR(VI)-AS(III) AND CR(III)-AS(III) SYSTEMS
    KOROLCZUK, M
    MATYSIK, J
    JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1980, 113 (02): : 265 - 271
  • [37] ION CHROMATOGRAPHIC-SEPARATION OF CR-III AND CR-VI AND SPECTROPHOTOMETRIC DETECTION OF CR-III-EDTA AND CR-VI-DPC SPECIES
    DEBEER, H
    COETZEE, PP
    SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE, 1991, 44 (04): : 105 - 109
  • [38] Determination of Cr(VI) and Cr(III) by FIA Method after Oxidation of Cr(III) by KIO4
    Chem Listy, 8 (585):
  • [39] Determination of Cr(VI) and Cr(III) by FIA method after oxidation of Cr(III) by KIO4
    Prochackova, T
    Foltin, M
    CHEMICKE LISTY, 1997, 91 (08): : 585 - 589
  • [40] Speciation-specific Cr bioaccumulation, morphologic and transcriptomic response in liver of Plectropomus leopardus exposed to dietary Cr(III) and Cr (VI)
    Wei, Lu
    Li, Qian
    Li, Huiying
    Ye, Hengzhen
    Han, Dong
    Guo, Zhiqiang
    Lek, Sovan
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2022, 241
12345