Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives

被引：35

作者：

Xu, Xiao-Liang ^{[1
]}

Yu, Chun-Lei ^{[2
]}

Chen, Wen ^{[1
]}

Li, Ying-Chao ^{[1
]}

Yang, Li-Juan ^{[3
,4
]}

Li, Yan ^{[2
]}

Zhang, Hong-Bin ^{[1
]}

Yang, Xiao-Dong ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

[3] Yunnan Minzu Univ, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650500, Peoples R China

[4] Yunnan Minzu Univ, Minist Educ, Kunming 650500, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 05期

关键词：

CYTOTOXIC ACTIVITIES; HYBRID COMPOUNDS; DESIGN; CHECKPOINT; AGENTS; TRANS;

D O I：

10.1039/c4ob02385d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of a substituted benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or 2-naphthylmethyl group were vital for modulating the cytotoxic activity. Compound 25 was found to be the most potent derivative with IC50 values of 0.24-1.18 mu M, and exhibited cytotoxic activity selectively against MCF-7, SW480, SMMC-7721 and HL-60 cell lines, while compound 26 showed powerful inhibitory activities selectively against SMMC-7721 and A549 cell lines. Compound 25 can induce G2/M phase cell cycle arrest and apoptosis in SMMC-7721 cells.

引用

页码：1550 / 1557

页数：8

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