Optimal control of the COVID-19 pandemic: controlled sanitary deconfinement in Portugal

被引:77
|
作者
Silva, Cristiana J. [1 ]
Cruz, Carla [1 ]
Torres, Delfim F. M. [1 ]
Munuzuri, Alberto P. [2 ]
Carballosa, Alejandro [2 ]
Area, Ivan [3 ]
Nieto, Juan J. [4 ]
Fonseca-Pinto, Rui [5 ]
Passadouro, Rui [5 ,6 ]
dos Santos, Estevao Soares [6 ]
Abreu, Wilson [7 ]
Mira, Jorge [8 ]
机构
[1] Univ Aveiro, Ctr Res & Dev Math & Applicat CIDMA, Dept Math, P-3810193 Aveiro, Portugal
[2] Univ Santiago Compostela, Inst CRETUS, Dept Phys, Grp Nonlinear Phys, Santiago De Compostela 15782, Spain
[3] Univ Vigo, Dept Matemat Aplicada EE Aeronaut & Espazo 2, Campus Ourense, Orense 32004, Spain
[4] Univ Santiago Compostela, Inst Matemat, Santiago De Compostela 15782, Spain
[5] Polytech Leiria, Ctr Innovat Care & Hlth Technol ciTechCare, Leiria, Portugal
[6] ACES Pinhal Litoral ARS Ctr, Leiria, Portugal
[7] ESEP CINTESIS, Sch Nursing & Res Ctr, Ctr Hlth Technol & Serv Res, Porto, Portugal
[8] Univ Santiago Compostela, Dept Fis Aplicada, Santiago De Compostela 15782, Spain
关键词
LOGISTIC MAP; TRANSMISSION; MODELS;
D O I
10.1038/s41598-021-83075-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The COVID-19 pandemic has forced policy makers to decree urgent confinements to stop a rapid and massive contagion. However, after that stage, societies are being forced to find an equilibrium between the need to reduce contagion rates and the need to reopen their economies. The experience hitherto lived has provided data on the evolution of the pandemic, in particular the population dynamics as a result of the public health measures enacted. This allows the formulation of forecasting mathematical models to anticipate the consequences of political decisions. Here we propose a model to do so and apply it to the case of Portugal. With a mathematical deterministic model, described by a system of ordinary differential equations, we fit the real evolution of COVID-19 in this country. After identification of the population readiness to follow social restrictions, by analyzing the social media, we incorporate this effect in a version of the model that allow us to check different scenarios. This is realized by considering a Monte Carlo discrete version of the previous model coupled via a complex network. Then, we apply optimal control theory to maximize the number of people returning to "normal life" and minimizing the number of active infected individuals with minimal economical costs while warranting a low level of hospitalizations. This work allows testing various scenarios of pandemic management (closure of sectors of the economy, partial/total compliance with protection measures by citizens, number of beds in intensive care units, etc.), ensuring the responsiveness of the health system, thus being a public health decision support tool.
引用
收藏
页数:15
相关论文
共 50 条
  • [31] Impact of the COVID-19 Pandemic on Ophthalmology Residency Training in Portugal
    Silva, Nisa
    Laiginhas, Rita
    Meireles, Angelina
    Breda, Joao Barbosa
    ACTA MEDICA PORTUGUESA, 2020, 33 (10): : 640 - 648
  • [32] The Challenge of Rehabilitation Medicine in Portugal During the COVID-19 Pandemic
    Martins, Cristiana Lopes
    Rios, Jonathan
    ACTA MEDICA PORTUGUESA, 2020, 33 (7-8): : 531 - 531
  • [33] Risk Communication and Community Engagement in the COVID-19 Pandemic in Portugal
    Teixeira, Pedro Miguel
    Vital Brito, Duarte
    Araujo, Rita
    Gomes, Bernardo
    ACTA MEDICA PORTUGUESA, 2021, 34 (01) : 1 - 2
  • [34] An optimal control model of COVID-19 pandemic: a comparative study of five countries
    Ali Khaleel Dhaiban
    Baydaa Khalaf Jabbar
    OPSEARCH, 2021, 58 : 790 - 809
  • [35] Adherence and sustainability of interventions informing optimal control against the COVID-19 pandemic
    Di Domenico, Laura
    Sabbatini, Chiara E.
    Boelle, Pierre-Yves
    Poletto, Chiara
    Crepey, Pascal
    Paireau, Juliette
    Cauchemez, Simon
    Beck, Francois
    Noel, Harold
    Levy-Bruhl, Daniel
    Colizza, Vittoria
    COMMUNICATIONS MEDICINE, 2021, 1 (01):
  • [36] Robust optimal control of compartmental models in epidemiology: Application to the COVID-19 pandemic
    Olivares, Alberto
    Staffetti, Ernesto
    COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION, 2022, 111
  • [37] Adherence and sustainability of interventions informing optimal control against the COVID-19 pandemic
    Laura Di Domenico
    Chiara E. Sabbatini
    Pierre-Yves Boëlle
    Chiara Poletto
    Pascal Crépey
    Juliette Paireau
    Simon Cauchemez
    François Beck
    Harold Noel
    Daniel Lévy-Bruhl
    Vittoria Colizza
    Communications Medicine, 1
  • [38] An optimal control model of COVID-19 pandemic: a comparative study of five countries
    Dhaiban, Ali Khaleel
    Jabbar, Baydaa Khalaf
    OPSEARCH, 2021, 58 (04) : 790 - 809
  • [39] Determination of an optimal control strategy for vaccine administration in COVID-19 pandemic treatment
    Libotte, Gustavo Barbosa
    Lobato, Fran Sergio
    Platt, Gustavo Mendes
    Silva Neto, Antonio J.
    COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 2020, 196
  • [40] A MATHEMATICAL MODELING WITH OPTIMAL CONTROL STRATEGY OF TRANSMISSION OF COVID-19 PANDEMIC VIRUS
    Kouidere, Abdelfatah
    Khajji, Bouchaib
    El Bhih, Amine
    Balatif, Omar
    Rachik, Mostafa
    COMMUNICATIONS IN MATHEMATICAL BIOLOGY AND NEUROSCIENCE, 2020, : 1 - 23