Optimal control of the COVID-19 pandemic: controlled sanitary deconfinement in Portugal

被引:77
|
作者
Silva, Cristiana J. [1 ]
Cruz, Carla [1 ]
Torres, Delfim F. M. [1 ]
Munuzuri, Alberto P. [2 ]
Carballosa, Alejandro [2 ]
Area, Ivan [3 ]
Nieto, Juan J. [4 ]
Fonseca-Pinto, Rui [5 ]
Passadouro, Rui [5 ,6 ]
dos Santos, Estevao Soares [6 ]
Abreu, Wilson [7 ]
Mira, Jorge [8 ]
机构
[1] Univ Aveiro, Ctr Res & Dev Math & Applicat CIDMA, Dept Math, P-3810193 Aveiro, Portugal
[2] Univ Santiago Compostela, Inst CRETUS, Dept Phys, Grp Nonlinear Phys, Santiago De Compostela 15782, Spain
[3] Univ Vigo, Dept Matemat Aplicada EE Aeronaut & Espazo 2, Campus Ourense, Orense 32004, Spain
[4] Univ Santiago Compostela, Inst Matemat, Santiago De Compostela 15782, Spain
[5] Polytech Leiria, Ctr Innovat Care & Hlth Technol ciTechCare, Leiria, Portugal
[6] ACES Pinhal Litoral ARS Ctr, Leiria, Portugal
[7] ESEP CINTESIS, Sch Nursing & Res Ctr, Ctr Hlth Technol & Serv Res, Porto, Portugal
[8] Univ Santiago Compostela, Dept Fis Aplicada, Santiago De Compostela 15782, Spain
关键词
LOGISTIC MAP; TRANSMISSION; MODELS;
D O I
10.1038/s41598-021-83075-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The COVID-19 pandemic has forced policy makers to decree urgent confinements to stop a rapid and massive contagion. However, after that stage, societies are being forced to find an equilibrium between the need to reduce contagion rates and the need to reopen their economies. The experience hitherto lived has provided data on the evolution of the pandemic, in particular the population dynamics as a result of the public health measures enacted. This allows the formulation of forecasting mathematical models to anticipate the consequences of political decisions. Here we propose a model to do so and apply it to the case of Portugal. With a mathematical deterministic model, described by a system of ordinary differential equations, we fit the real evolution of COVID-19 in this country. After identification of the population readiness to follow social restrictions, by analyzing the social media, we incorporate this effect in a version of the model that allow us to check different scenarios. This is realized by considering a Monte Carlo discrete version of the previous model coupled via a complex network. Then, we apply optimal control theory to maximize the number of people returning to "normal life" and minimizing the number of active infected individuals with minimal economical costs while warranting a low level of hospitalizations. This work allows testing various scenarios of pandemic management (closure of sectors of the economy, partial/total compliance with protection measures by citizens, number of beds in intensive care units, etc.), ensuring the responsiveness of the health system, thus being a public health decision support tool.
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页数:15
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