Flow injection-spectrophotometric determination of metoclopramide hydrochloride

The determination of metoclopramide hydrochloride is spectrophotometrically determined by the Bratton-Marshall method in a flow injection assembly. The required nitrite is prepared on-line in the flow assembly by reducing a nitrate solution with the aid of a copperised cadmium solid-phase reactor. The calibration graph is linear over the range 0.5-85 mg l(-1), with a relative standard deviation (RSD) of 0.89%, and sample throughput of 51 samples h(-1). The method is easy and simple, and it is applied to determination of metoclopramide in some pharmaceutical formulations. The method eliminates the need for frequent preparation of unstable nitrite solutions. (C) 1998 Elsevier Science B.V. All rights reserved.