Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity

被引：7

作者：

Samanta, Kartick Chandra ^{[1
]}

Asif, Mohd ^{[2
]}

Pooja ^{[1
]}

Garg, Vikas ^{[3
]}

Sharma, Priyanka ^{[1
]}

Singh, Ravinder ^{[4
]}

机构：

[1] Suresh Gyan Vihar Univ, Sch Pharm, Jaipur 302025, Rajasthan, India

[2] GRD PG Inst Management & Technol, Dept Pharm, Dehra Dun, Uttarakhand, India

[3] Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India

[4] Nandha Coll Pharm & Res Inst, Erode, Tamil Nadu, India

来源：

E-JOURNAL OF CHEMISTRY | 2011年 / 8卷 / 01期

关键词：

Anticonvulsant; Cyclization; MES; Pyridazinone;

D O I：

10.1155/2011/873470

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

6-Phenyl(3'-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3'-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriate beta-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity.

引用

页码：245 / 251

页数：7

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