Neoantigen Vaccines Pass the Immunogenicity Test

被引：35

作者：

Linette, Gerald P. ^{[1
,2
]}

Carreno, Beatriz M. ^{[2
,3
]}

机构：

[1] Univ Penn, Perelman Sch Med, Parker Inst Canc Immunotherapy, Dept Hematol Oncol, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Parker Inst Canc Immunotherapy, Philadelphia, PA 19104 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.molmed.2017.08.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neoantigens arising from tumor-specific genomic alterations constitute authentic non-self antigens and represent a new class of targets for cancer immunotherapy. Recent reports on various vaccine platforms targeting neoantigens suggest a basis for precision therapies customized to each patient's tumor mutational profile.

引用

页码：869 / 871

页数：3

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