Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

被引：11

作者：

Meerovich, I. G. ^{[1
,2
]}

Sanarova, E. V. ^{[1
]}

Meerovich, G. A. ^{[3
]}

Derkacheva, V. M. ^{[4
]}

Volkov, K. A. ^{[4
]}

Negrimovsky, V. M. ^{[4
]}

Barkanova, S. V. ^{[4
]}

Lukyanets, E. A. ^{[4
]}

Oborotova, N. A. ^{[1
]}

Smirnova, Z. S. ^{[1
]}

Borisova, L. M. ^{[1
]}

Lantsova, A. V. ^{[1
]}

Polozkova, A. P. ^{[1
]}

Orlova, O. L. ^{[1
]}

Loschenov, V. B. ^{[3
]}

Umnova, L. V. ^{[4
]}

Baryshnikov, A. Yu ^{[1
]}

Vorozhtsov, G. N. ^{[4
]}

机构：

[1] NN Blokhin Russian Canc Res Ctr, Moscow 115478, Russia

[2] Creighton Univ, Omaha, NE 68178 USA

[3] Russian Acad Sci, Prokhorov Inst Gen Phys, Moscow, Russia

[4] FSUE SSC NIOPIK, Moscow, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2015年 / 85卷 / 01期

关键词：

PHOTODYNAMIC THERAPY;

D O I：

10.1134/S1070363215010430

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The research is devoted to development and study of photosensitizers on a base of injectable nanoparticular formulations of phthalocyanine derivatives absorbing at long wavelength (near-infrared) range of 710-740 nm: Thiosens [liposomal form of aluminum hydroxide 1,8,15,22-tetrakis(phenylsulfanyl)phthalocyanine] and Octasens [polymeric micellar form of zinc 1,4,8,11,15,18,22,25-octachloro-2,3,9,10,16,17,23,24-octakis-(decylsulfanyl)phthalocyanine based on domestic poloxamer Emuxol-268]. Experiments have shown that the photosensitizers under study show high selectivity of accumulation and prolonged retaining at high concentration in tumor, relatively fast clearance from normal tissue and high therapeutic efficiency of photodynamic treatment on model tumors.

引用

页码：280 / 288

页数：9

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