Serotype Distribution and Susceptibility of Streptococcus pneumoniae Isolates from Pleural Fluid in Spain from 1997 to 2008

被引:8
|
作者
Fenoll, A. [2 ]
Aguilar, L. [1 ]
Vicioso, M. D. [2 ]
Gimenez, M. J. [1 ]
Robledo, O. [2 ]
Granizo, J. J. [3 ]
Mendez, C. [4 ]
机构
[1] Univ Complutense, Sch Med, Dept Microbiol, E-28040 Madrid, Spain
[2] Inst Salud Carlos III, Spanish Reference Pneumococcal Lab, Madrid, Spain
[3] Grana Datos, Madrid, Spain
[4] Pfizer SA, Dept Med, Madrid, Spain
关键词
PNEUMOCOCCAL CONJUGATE VACCINE; PARAPNEUMONIC EMPYEMA; NONVACCINE SEROTYPES; CHILDREN; DISEASE; RESISTANCE; EMERGENCE; IMPACT;
D O I
10.1128/AAC.00217-10
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Trends in serotype incidence and susceptibility (1997 to 2008) of Spanish Streptococcus pneumoniae pleural isolates (n = 831) were explored. Penicillin (oral) nonsusceptibility rates and the incidence of 7-valent pneumococcal conjugate vaccine (PCV-7) serotypes showed decreasing trends (R-2 >= 0.600; P <= 0.002). The incidence of serotypes 1 and 19A showed increasing trends (R-2 >= 0.759; P < 0.001), with no trends for serotype 3. Serotypes 19A, 1, and 3 represented 85% of pediatric isolates in 2008. In serotype 19A, the penicillin nonsusceptibility rate was 82.4% in 2008, associated with amoxicillin and cefotaxime nonsusceptibility in 21.4% of isolates. Inclusion of these serotypes in new vaccines offers the broadest coverage.
引用
收藏
页码:5387 / 5390
页数:4
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