High-resolution melting assay for genotyping of IFNL4-associated dinucleotide variant rs368234815

被引：2

作者：

Galmozzi, E. ^{[1
]}

Facchetti, F. ^{[1
]}

Perbellini, R. ^{[1
]}

Aghemo, A. ^{[1
]}

机构：

[1] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Gastroenterol & Hepatol, Milan, Italy

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2014年 / 20卷 / 11期

关键词：

hepatitis C virus; high-resolution melting; IFNL4; IL28B; RT-PCR; PEGYLATED INTERFERON-ALPHA; HEPATITIS-C; SPONTANEOUS CLEARANCE; GENETIC-VARIATION; IL28B; POLYMORPHISM; ASSOCIATION; RIBAVIRIN; THERAPY; ALLELE;

D O I：

10.1111/1469-0691.12637

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Interferon-4-related dinucleotide variant rs368234815 TT/-G is strongly linked with rs12979860 polymorphism, the most important genetic marker connected to treatment-induced hepatitis C virus clearance. Due to additional baseline information that rs368234815 polymorphism could provide for the management of chronic hepatitis C, we developed and validated a high-resolution melting genotyping assay using 193 patients with chronic hepatitis C.

引用

页码：O936 / O938

页数：3

共 36 条

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