False negative results in the Roche assay for HDL-cholesterol

被引：9
|
作者：
Bakker, AJ
机构：
[1] Stichting Klin Chem Lab, Dept Clin Chem, NL-8901 BR Leeuwarden, Netherlands
[2] Med Ctr Leeuwarden, Dept Internal Med, Leeuwarden, Netherlands
来源：
ANNALS OF CLINICAL BIOCHEMISTRY | 2003年 / 40卷
关键词：
D O I：
10.1258/000456303322326533
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Measurement of HDL-cholesterol is important in the risk evaluation of cardiovascular disease. Recently, we encountered a 61-year-old man with a negative result for HDL-cholesterol using the Roche assay. Further analysis revealed that this patient had a monoclonal Ig type IgMkappa, with an electrophoresis-based concentration of 55.8 g/L, which apparently caused the negative result for HDL-cholesterol. Analysis of serum samples from other patients with monoclonal or polyclonal hypergammaglobulinaemia revealed that false negative results in the Roche assay for HDL-cholesterol may occur incidentally. Since negative results are detected easily in the laboratory, such patients do not pose a problem in daily practice. However, it is reasonable to suppose that false low results could also be caused by monoclonal as well as polyclonal Igs. Since such false low results remain undetected, vascular risk estimates consequently are altered and unnecessary treatment might be started.
引用
收藏
页码：572 / 575
页数：4
相关论文
共 50 条
  • [21] Evaluation of precipitation and direct methods for HDL-cholesterol assay by HPLC
    Okazaki, M
    Sasamoto, K
    Muramatsu, T
    Hosaki, S
    CLINICAL CHEMISTRY, 1997, 43 (10) : 1885 - 1890
  • [22] Evaluation of a new homogeneous assay for the quantitative determination of the HDL-cholesterol
    Larrose, C
    Piton, JC
    Richeux, G
    Bard, JM
    Orsonneau, JL
    ANNALES DE BIOLOGIE CLINIQUE, 1998, 56 (01) : 108 - 111
  • [23] DEVELOPMENT OF AN AUTOMATED ASSAY FOR APOE-CONTAINING HDL-CHOLESTEROL
    Takahashi, Y.
    Sakurai, T.
    Fujikawa, M.
    Nagasaka, A.
    Hui, S.
    Jin, S.
    Takeda, S.
    Fuda, H.
    Ito, Y.
    Chiba, H.
    ATHEROSCLEROSIS, 2014, 235 (02) : E102 - E102
  • [24] Multicenter evaluation of a new HDL-cholesterol reagent on Roche/Hitachi and COBAS INTEGRA® systems
    Domke, I.
    Grawitz, A. Busse
    Cole, T. G.
    Fresi, P.
    Hoefner, D.
    Leary, E. T.
    Lindemans, J.
    Plecko, T.
    Giovantin, E. Reverso
    Winkler, K.
    Zwang, R.
    Bruton, D.
    Klima, H.
    CLINICAL CHEMISTRY, 2006, 52 (06) : A113 - A113
  • [25] Dual HDL total cholesterol test: a new homogenous assay for the sequential measurement of HDL-cholesterol and total cholesterol.
    Sampson, ML
    Csako, G
    Remaley, AT
    CLINICAL CHEMISTRY, 1999, 45 (06) : A15 - A15
  • [26] Analytical performance of the Roche direct HDL-cholesterol assay compared with the ultracentrifugation-dextran sulfate-Mg++ method.
    Law, T
    DeAngelis, K
    Arslanian, S
    Iannotti, E
    Rifai, N
    CLINICAL CHEMISTRY, 1998, 44 : A77 - A77
  • [27] CHOLESTEROL AND HDL-CHOLESTEROL IN THE POPULATION OF VIENNA
    TROMBIK, E
    FRASS, M
    MULLER, MM
    JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY, 1981, 19 (04): : 240 - 240
  • [28] Dynamic reaction in a homogeneous HDL-cholesterol assay visualized by electron microscopy
    Kondo, A
    Muranaka, Y
    Ohta, I
    Kanno, T
    CLINICAL CHEMISTRY, 1999, 45 (11) : 1974 - 1980
  • [29] COMPARATIVE-STUDY OF 4 HDL-CHOLESTEROL ASSAY-METHODS
    CHICAUD, P
    LAMBERT, D
    MEJEAN, L
    DROUIN, P
    DEBRY, G
    CLINICA CHIMICA ACTA, 1981, 116 (01) : 55 - 62
  • [30] THE RELATIONSHIP BETWEEN HDL-CHOLESTEROL AND HDL FUNCTION
    Wade, L.
    Widdowson, M.
    Mcgown, A.
    Gibney, J.
    Thies, F.
    Mcginty, A.
    Young, I.
    McEneny, J.
    ATHEROSCLEROSIS SUPPLEMENTS, 2011, 12 (01) : 107 - 108
12345