Covariation of plasma ghrelin and motilin in irritable bowel syndrome

被引:43
|
作者
Sjolund, Kristina [1 ,2 ]
Ekman, Rolf [3 ]
Wierup, Nils [4 ]
机构
[1] Trelleborg Hosp, Dept Internal Med, S-23185 Trelleborg, Sweden
[2] Lund Univ, Div Med, Dept Clin Sci, Lund, Sweden
[3] Gothenburg Univ, Sahlgrenska Univ Hosp, Neurochem Lab, Inst Neurosci & Physiol, Molndal, Sweden
[4] Lund Univ, Dept Expt Med Sci, Lund, Sweden
基金
英国医学研究理事会;
关键词
Irritable bowel disease; Gut peptides; Ghrelin; Motilin; Small intestinal manometry; CIRCULATING GHRELIN; SECRETION; RECEPTOR; STOMACH; PEPTIDE; MEAL;
D O I
10.1016/j.peptides.2010.03.021
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have previously shown that ghrelin is mainly localized to the stomach but also occurs, together with the prokinetic hormone motilin, in endocrine cells in the proximal small intestine. This study explored ghrelin and motilin concentrations in plasma in relation to gastrointestinal motility and whether plasma ghrelin is changed in patients with irritable bowel syndrome (IBS). Nine patients with severe IBS and 10 healthy subjects underwent stationary antro-duodeni-jejunal manometry; blood was sampled during similar motility phases in the two groups. The motility phases were monitored and blood samples were collected during fasting and after food intake. Plasma was analyzed for two forms of ghrelin (octanylated and desoctanylated) as well as for motilin. In IBS patients circulating motilin levels covaried with total ghrelin levels (r = 0.90; p < 0.004), octanylated ghrelin (r = 0.77; p < 0.02) and desoctanylated ghrelin (r = 0.69; p < 0.04). No such correlations were seen in the control group. Octanylated ghrelin comprised 35.3 +/- 3.9% (mean +/- SEM) of the total circulating ghrelin in the IBS patients compared to 40.4 +/- 4.5% (mean +/- SEM) in the control group (NS). Ghrelin covaried with motilin in plasma in IBS but not in plasma from healthy subjects. This suggests the two peptides act together in IBS. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:1109 / 1112
页数:4
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