Therapeutic vaccine JNJ-0535 induces a strong HBV-specific T-cell response in healthy adults and a modest response in chronic HBV-infected patients

被引：0
|
作者：
De Creus, An [1 ]
Slaets, Leen [1 ]
Fevery, Bart [1 ]
Van Gulck, Ellen [1 ]
Zhou, Linghua [1 ]
Van De Parre, Tim [1 ]
Van Den Broeke, Celine [1 ]
Dimitrova, Dessislava [2 ]
Lonjon-Domanec, Isabelle [1 ]
Blue, David, Jr. [3 ]
Van Remoortere, Pieter [2 ]
Bourgeois, Stefan [4 ]
Kennedy, Patrick [5 ]
De Meyer, Sandra
机构：
[1] Janssen Res & Dev, Beerse, Belgium
[2] Janssen Res & Dev, Raritan, NJ 08869 USA
[3] Janssen Biopharma Inc, Horsham, PA USA
[4] Hosp Network Antwerp ZNA, Antwerp, Belgium
[5] Barts & London Queen Marys Sch Med & Dent, London, England
来源：
JOURNAL OF HEPATOLOGY | 2022年 / 77卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
OS094
引用
收藏
页码：S72 / S73
页数：2
相关论文
共 26 条
  • [21] Chronic restraint stress induces severe disruption of the T-cell specific response to tetanus toxin vaccine (vol 102, pg 87, 2001)
    Tournier, JN
    Mathieu, J
    Mailfert, Y
    Multon, E
    Drouet, C
    Jouan, A
    Drouet, E
    IMMUNOLOGY, 2001, 102 (04) : 515 - 515
  • [22] Phenotypic variation among myeloid-derived suppressor cells (MDSC) in natural history phases of chronic HBV infection differentially impacts HBV-specific T cell response and homing: lack of functional normalization after anti-viral therapy
    Pal, Sourina
    Dey, Debangana
    Nandi, Madhuparna
    Goswami, Archi
    Khatun, Mousumi
    Banerjee, Soma
    Santra, Amal K.
    Ahammed, Sk. Mahiuddin
    Chowdhury, Abhijit
    Datta, Simanti
    JOURNAL OF HEPATOLOGY, 2020, 73 : S578 - S578
  • [23] DNA/MVA Therapeutic Vaccination Induces Robust Polyfunctional SIV-Specific T-Cell Response and Antigen Recognition Breadth in Chronically SIVmac239-Infected Rhesus Macaques Under ART
    Rahman, Sheikh Abdul
    Yagnik, Bhrugu
    Bally, Alexander P.
    Morrow, Kristen
    Freeman, Gordan J.
    Ahmed, Rafi
    Amara, Rama Rao
    JOURNAL OF MEDICAL PRIMATOLOGY, 2020, 49 (05) : 261 - 261
  • [24] The receptor for hyaluronic acid-mediated motility induces specific CD8+ T cell response in healthy donors and patients with chronic myeloid leukemia after allogeneic stem cell transplantation
    Chen, Jinfei
    Schmitt, Anita
    Bunjes, Donald
    Chen, Baoan
    Schmitt, Michael
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2007, 30 (05) : 1119 - 1127
  • [25] Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three Adjuvant Systems
    Leroux-Roels, Isabel
    Koutsoukos, Marguerite
    Clement, Frederic
    Steyaert, Sophia
    Janssens, Michel
    Bourguignon, Patricia
    Cohen, Kristen
    Altfeld, Marcus
    Vandepapeliere, Pierre
    Pedneault, Louise
    McNally, Lisa
    Leroux-Roels, Geert
    Voss, Gerald
    VACCINE, 2010, 28 (43) : 7016 - 7024
  • [26] Interferon alpha in combination with GM-CSF induces the differentiation of leukaemic antigen-presenting cells that have the capacity to stimulate a specific anti-leukaemic cytotoxic T-cell response from patients with chronic myeloid leukaemia
    Chen, X
    Regn, S
    Raffegerst, S
    Kolb, HJ
    Roskrow, M
    BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (02) : 596 - 607
123