Age and Sex Differences in the Clustering of Metabolic Syndrome Factors

被引:161
|
作者
Kuk, Jennifer L. [1 ]
Ardern, Chris I. [1 ]
机构
[1] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 2R7, Canada
关键词
ALL-CAUSE MORTALITY; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; ASSOCIATION; RISK;
D O I
10.2337/dc10-0942
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - The metabolic syndrome is a general term given to a clustering of cardiom-etabolic risk factors that may consist of different phenotype combinations. The purpose of this study was to determine the prevalence of the different combinations of factors that make up the metabolic syndrome as defined by the National Cholesterol Education Program and to examine their association with all-cause mortality in younger and older men and women. RESEARCH DESIGN AND METHODS - A total of 2,784 men and 3,240 women from the Third National Health and Nutrition Examination Survey with public-access mortality data linkage (follow-up = 14.2 +/- 0.2 years) were studied. RESULTS - Metabolic syndrome was present in 26% of younger (aged <= 65 years) and 55.0% of older (aged >65 years) participants. The most prevalent metabolic syndrome combination was the clustering of high triglycerides, low HDL cholesterol, and elevated blood pressure in younger men (4.8%) and triglycerides, HDL cholesterol, and elevated waist circumference in younger women (4.2%). The presence of all five metabolic syndrome factors was the most common metabolic syndrome combination in both older men (8.0%) and women (9.2%). Variation existed in how metabolic syndrome combinations were associated with mortality. In younger adults, having all five metabolic syndrome factors was most strongly associated with mortality risk, whereas in older men, none of metabolic syndrome combinations were associated with mortality. In older women, having elevated glucose or low HDL as one of the metabolic syndrome components was most strongly associated with mortality risk. CONCLUSIONS - Metabolic syndrome is a heterogeneous entity with age and sex variation in component clusters that may have important implications for interpreting the association between metabolic syndrome and mortality risk. Thus, metabolic syndrome used as a whole may mask important differences in assessing health and mortality risk.
引用
收藏
页码:2457 / 2461
页数:5
相关论文
共 50 条
  • [21] Age, alcohol, sex, and metabolic factors as risk factors for colonic diverticulosis
    Yan, Ye
    Wu, Jian-Sheng
    Pan, Shuang
    WORLD JOURNAL OF CLINICAL CASES, 2022, 10 (01) : 136 - 142
  • [22] Age, alcohol, sex, and metabolic factors as risk factors for colonic diverticulosis
    Ye Yan
    Jian-Sheng Wu
    Shuang Pan
    World Journal of Clinical Cases, 2022, (01) : 136 - 142
  • [23] Sex Differences in High Sensitivity C-Reactive Protein in Subjects with Risk Factors of Metabolic Syndrome
    Garcia, Vinicius Pacheco
    Miguens Rocha, Helena Naly
    Kluser Sales, Allan Robson
    Rocha, Natalia Galito
    Lucas da Nobrega, Antonio Claudio
    ARQUIVOS BRASILEIROS DE CARDIOLOGIA, 2016, 106 (03) : 182 - 186
  • [24] Sex Differences In Venous Thrombus Resolution In Mice With Metabolic Syndrome
    Nguyen, Khanh P.
    Nguyen, Kevin
    Setthavongsack, Naly
    Ngu, Daphne
    Vo, Anthony
    Faik, Sarah
    Woltjer, Randall
    Hinds, Monica T.
    Loftis, Jennifer
    Maloyan, Alina
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2024, 44
  • [25] Sex Differences in the Metabolic Syndrome: Implications for Cardiovascular Health in Women
    Pradhan, Aruna D.
    CLINICAL CHEMISTRY, 2014, 60 (01) : 44 - 52
  • [26] Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease
    Suh, Sunghwan
    Baek, Jongha
    Bae, Ji Cheol
    Kim, Kyoung-Nyoun
    Park, Mi Kyoung
    Kim, Duk Kyu
    Cho, Nam H.
    Lee, Moon-Kyu
    ENDOCRINOLOGY AND METABOLISM, 2014, 29 (04) : 522 - 529
  • [27] Sex Differences in the Progression of Metabolic Risk Factors in Diabetes Development
    Yoshida, Yilin
    Chen, Zhipeng
    Baudier, Robin L.
    Krousel-Wood, Marie
    Anderson, Amanda H.
    Fonseca, Vivian A.
    Mauvais-Jarvis, Franck
    JAMA NETWORK OPEN, 2022, 5 (07) : E2222070
  • [28] Sex differences and risk factors for bleeding in Alagille syndrome
    Hankeova, Simona
    Van Hul, Noemi
    Laznovsky, Jakub
    Verboven, Elisabeth
    Mangold, Katrin
    Hensens, Naomi
    Adori, Csaba
    Verhoef, Elvira
    Zikmund, Tomas
    Dawit, Feven
    Kavkova, Michaela
    Salplachta, Jakub
    Sjoqvist, Marika
    Johansson, Bengt R.
    Hassan, Mohamed G.
    Fredriksson, Linda
    Baumgartel, Karsten
    Bryja, Vitezslav
    Lendahl, Urban
    Jheon, Andrew
    Alten, Florian
    Fahnehjelm, Kristina Tear
    Fischler, Bjorn
    Kaiser, Jozef
    Andersson, Emma R.
    EMBO MOLECULAR MEDICINE, 2022, 14 (12)
  • [29] Physical fitness and clustering of risk factors associated with the metabolic syndrome
    Whaley, MH
    Kampert, JB
    Kohl, HW
    Blair, SN
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1999, 31 (02): : 287 - 293
  • [30] Clustering of novel risk factors correlates with the metabolic syndrome.
    Hook, MA
    Chiu, JH
    Messerli, A
    Griffin, BP
    Pearce, GL
    Sprecher, DL
    CIRCULATION, 2004, 109 (07) : E115 - E115