Synthesis of (E)-4,5-Dihydro-1H-Pyrazoles via Tandem Intermolecular Addition-Cyclization of N-Propargylic Sulfonylhydrazones

被引：0
|
作者：
Tang, Hai-Tao
Zeng, Jia-Hao
Chen, Jun-Jia
Chen, Yi-Hui [1 ]
Zhan, Zhuang-Ping
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China
来源：
SYNLETT | 2017年 / 28卷 / 15期
基金：
中国国家自然科学基金;
关键词：
propargyl hydrazones; dihydropyrazoles; acetals; intermolecular reaction; DIHYDROPYRAZOLE DERIVATIVES; SUBSTITUTED PYRAZOLES; ACCESS; ANNULATION; INHIBITORS; CASCADE; UTILITY; ESTERS; POTENT; AGENTS;
D O I：
10.1055/s-0036-1588844
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new strategy for the synthesis of (E)-4-benzylidene-4,5-dihydro-1H-pyrazoles through tandem intermolecular addition-intramolecular cyclization of N-propargylic sulfonylhydrazones has been developed. In this study, we firstly report that N-propargylic sulfonylhydrazones react with electrophilic reagents to afford 4-substituted pyrazole derivatives.
引用
收藏
页码：2036 / 2040
页数：5
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