Role of neurotrophin in the taste system following gustatory nerve injury

被引：3
|
作者：
Meng, Lingbin [1 ]
Jiang, Xin [2 ]
Ji, Rui [3 ]
机构：
[1] Univ Louisville, Sch Med, Dept Anat Sci & Neurobiol, Louisville, KY 40202 USA
[2] Jilin Univ, Dept Radiat Oncol, Hosp 1, Changchun 130021, Peoples R China
[3] Univ Louisville, Sch Med, Dept Biochem & Mol Biol, Louisville, KY 40202 USA
来源：
METABOLIC BRAIN DISEASE | 2015年 / 30卷 / 03期
关键词：
Neurotrophin; Taste system; Geniculate ganglion; Taste bud; Chorda tympani nerve; CHORDA TYMPANI NERVE; RETINAL GANGLION-CELLS; DIETARY-SODIUM RESTRICTION; PRIMARY SENSORY NEURONS; DORSAL-ROOT GANGLIA; GENICULATE GANGLION; LINGUAL NERVE; SPINAL-CORD; ADULT-RATS; FUNGIFORM PAPILLAE;
D O I：
10.1007/s11011-014-9626-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Taste system is a perfect system to study degeneration and regeneration after nerve injury because the taste system is highly plastic and the regeneraton is robust. Besides, degeneration and regeneration can be easily measured since taste buds arise in discrete locations, and nerves that innervate them can be accurately quantified. Neurotrophins are a family of proteins that regulate neural surival, function, and plasticity after nerve injury. Recent studies have shown that neurotrophins play an important role in the developmental and mature taste system, indicating neurtrophin might also regulate taste system following gustatory nerve injury. This review will summarize how taste system degenerates and regenerates after gustatory nerve cut and conclude potential roles of neurotrophin in regulating the process.
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页码：605 / 613
页数：9
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