Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by 1H NMR Spectroscopy

被引：1
|
作者：
Kuz'mina, N. E. [1 ]
Moiseev, S. V. [1 ]
Krylov, V. I. [1 ]
Yashkir, V. A. [1 ]
Merkulov, V. A. [1 ]
机构：
[1] Russian Minist Hlth, Sci Ctr Expert Evaluat Med Prod, 8 Petrovskii Blvd, Moscow 127051, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 04期
关键词：
hydroxyethylstarches; molar substitution; validation of method; H-1 NMR spectroscopy;
D O I：
10.1007/s11094-016-1435-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Amethod for determining molar substitution of hydroxyethylstarches by H-1 NMR spectroscopy was validated in terms of specificity, linearity, correctness, precision, and range of application. The method can be used to evaluate the parameter "molar substitution" in the framework of pharmacological expert assessment of hydroxyethylstarches as components of medicines.
引用
收藏
页码：265 / 269
页数：5
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