How many ELNs are optimal for breast cancer patients with more than three PLNs who underwent MRM? A large population-based study

被引：1
|
作者：
Wang, Xiaohui [1 ]
Ji, Changbin [2 ]
Chi, Huiying [3 ]
Wang, Haiyong [4 ]
机构：
[1] Shandong Liaocheng Peoples Hosp, Res Serv Off, Liaocheng, Peoples R China
[2] Shandong Liaocheng Peoples Hosp, Orthoped Dept, Liaocheng, Peoples R China
[3] Shanghai Geriatr Inst Tradit Chinese Med, Shanghai, Peoples R China
[4] Shandong Univ, Shandong Acad Med Sci, Dept Internal Med Oncol, Shandong Canc Hosp & Inst,Shandong Canc Hosp, 440 Jiyan Rd, Jinan 250117, Shandong, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2018年 / 11卷
基金：
中国国家自然科学基金;
关键词：
breast cancer; mastectomy; ELNs; positive lymph nodes; X-tile; LYMPH-NODE RATIO; STAGING SYSTEM; SURVIVAL; NUMBER; BIOPSY;
D O I：
10.2147/OTT.S152936
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Few studies have focused on the optimal threshold of examed lymph nodes (ELNs) for breast cancer patients with more than three positive lymph nodes after modified radical mastectomy. Materials and methods: The X-tile and the minimum P-value models were applied to determine the optimal threshold. Cox proportional hazard analysis was used to analyze the cancer-specific survival and perform subgroup analysis. Results: The results showed that 12 ELNs was the optimal threshold for these patients, and the patients with >12 ELNs had a better cancer-specific survival benefit compared with the patients with <12 ELNs (P < 0.001). Conclusion: The number 12 can be selected as the optimal threshold of ELNs for breast cancer patients with >3 positive lymph nodes after modified radical mastectomy.
引用
收藏
页码：1005 / 1011
页数：7
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