Synthesis and Pharmacological Activities of Pyrano[2,3-d] pyrimidine and Pyrano[2,3-d] pyrimidine-5-one Derivatives as New Fused Heterocyclic Systems

被引：16
|
作者：
Mahmoud, Naglaa F. H. [1 ]
El-Bordany, Eman A. [1 ]
Elsayed, Galal A. [1 ]
机构：
[1] Ain Shams Univ, Fac Sci, Chem Dept, Cairo 11566, Egypt
来源：
JOURNAL OF CHEMISTRY | 2017年 / 2017卷
关键词：
IN-VITRO; BIOLOGICAL EVALUATION; DESIGN; SERIES; QUINAZOLINE;
D O I：
10.1155/2017/5373049
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Various fused oxazine such as 4-(4-methoxyphenyl)-3,7-dimethyl-1,4-dihydro-5H-pyrazolo [4',3':5,6] pyrano[ 2,3-d][ 1,3] oxazin5-one 2 has been prepared and utilized as a starting material for novel pyrazolopyranopyrimidinones 3, 5, 6, and 7a-c and pyrazolopyranopyrimidines 4, 9, 10, and 11 which are expected to possess considerable chemical and pharmacological activities. The structures of the new compounds have been elucidated by spectroscopic data and elemental analysis. The antioxidant and anticancer activities of synthesized products have been evaluated.
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页数：7
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