Detrimental Effects of Divalproex on Warfarin Therapy Following Mechanical Valve Replacement

被引：2
|
作者：
Nadkarni, Ashwini [1 ]
Oldham, Mark [1 ]
Howard, Mark [1 ]
Lazar, Harold L. [2 ]
Berenbaum, Isidore [1 ]
机构：
[1] Boston Univ, Dept Psychiat, Boston Med Ctr, Sch Med, Boston, MA 02118 USA
[2] Boston Univ, Dept Cardiothorac Surg, Boston Med Ctr, Sch Med, Boston, MA 02118 USA
来源：
JOURNAL OF CARDIAC SURGERY | 2011年 / 26卷 / 05期
关键词：
VALPROIC ACID; BINDING;
D O I：
10.1111/j.1540-8191.2011.01293.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Drug interaction between Warfarin and psychiatric agents may have important therapeutic effects for patients undergoing cardiac surgery. We present a case of a patient in whom concurrent treatment with Warfarin and valproic acid resulted in supratherapeutic international normalized ratio values. A discussion of the possible mechanisms for this interaction as well as a review of interactions between Warfarin and other psychiatric medications is the subject of this case report. doi: 10.1111/j.1540-8191.2011.01293.x (J Card Surg 2011;26:492-494)
引用
收藏
页码：492 / 494
页数：3
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