A Single-Particle Trigger for Time-of-Flight Measurements in Prompt-Gamma Imaging

被引：8

作者：

Martins, Paulo Magalhaes ^{[1
,2
]}

Dal Bello, Riccardo ^{[1
,3
]}

Seimetz, Michael ^{[4
]}

Hermann, German ^{[5
]}

Kihm, Thomas ^{[5
]}

Seco, Joao ^{[1
,3
]}

机构：

[1] German Canc Res Ctr, Heidelberg, Germany

[2] Univ Lisbon, Inst Biofis & Engn Biomed, Fac Ciencias, Lisbon, Portugal

[3] Heidelberg Univ, Dept Phys & Astron, Heidelberg, Germany

[4] Univ Politecn Valencia, Inst Instrumentac Imagen Mol I3M, CSIC, Valencia, Spain

[5] Max Planck Inst Nucl Phys, Heidelberg, Germany

来源：

FRONTIERS IN PHYSICS | 2020年 / 8卷

关键词：

prompt-gamma; particle tracking; scintillating fibers; ion-beam therapy; synchrotrons; PROTON RANGE VERIFICATION; PLASTIC SCINTILLATION DETECTORS; ENERGY BEAM DOSIMETRY; RANDOM COINCIDENCES; PET MEASUREMENTS; SLIT CAMERA; PHOTON; SYSTEM; RAYS;

D O I：

10.3389/fphy.2020.00169

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Tracking of single particles accelerated by synchrotrons is a subject that crosses several physics fields. The high clinical intensities used in particle therapy that can exceed 10(9)p/s make this task very challenging. The tracking of the arrival time of single particles in the ion beam is fundamental for the verification of the particle range and dose delivered to the patient. We present a prototype made of scintillating fibers which has been used to provide time-of-flight (TOF) information for three beam species currently accelerated at the Heidelberg Ion-Beam Therapy Center (HIT). We have demonstrated a time-tracker for a prompt-gamma spectroscopy system that allows for a background TOF rejection with a sub-nanosecond time resolution.

引用

页数：13

共 50 条

[41] Time-of-flight trigger based on a time-to-amplitude converter
Ladygin, VP
Man'yakov, PK
Reznikov, SG
INSTRUMENTS AND EXPERIMENTAL TECHNIQUES, 2001, 44 (03) : 352 - 358
[42] In vivo total body chlorine measurements using prompt-gamma neutron activation analysis
R. J. Shypailo
K. J. Ellis
Journal of Radioanalytical and Nuclear Chemistry, 1998, 236 : 19 - 23
[43] In vivo total body chlorine measurements using prompt-gamma neutron activation analysis
Shypailo, RJ
Ellis, KJ
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 1998, 236 (1-2) : 19 - 23
[44] A NEW TIME-OF-FLIGHT PARTICLE DETECTOR
MUGA, ML
BURNSED, DJ
STEEGER, WE
TAYLOR, HE
NUCLEAR INSTRUMENTS & METHODS, 1970, 83 (01): : 135 - &
[45] PARTICLE DISCRIMINATION BY TIME-OF-FLIGHT METHODS
GEMMELL, DS
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1964, NS11 (03) : 409 - &
[46] TIME-OF-FLIGHT MEASUREMENT OF PARTICLE VELOCITY
LADERMAN, AJ
LEWIS, CH
BYRON, SR
AIAA JOURNAL, 1969, 7 (03) : 556 - &
[47] A TIME-OF-FLIGHT PARTICLE IDENTIFICATION SYSTEM
BLIGNAUT, E
MCMURRAY, WR
BOTTEGA, A
NUCLEAR INSTRUMENTS & METHODS, 1967, 51 (01): : 102 - &
[48] Single-particle detection efficiencies of aerosol time-of-flight mass spectrometry during the North Atlantic marine boundary layer experiment
Dall'Osto, Manuel
Harrison, Roy M.
Beddows, David C. S.
Freney, Evelyn J.
Heal, Mathew R.
Donovan, Robert J.
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2006, 40 (16) : 5029 - 5035
[49] Monte Carlo Simulation of Low-Count Signals in Time-of-Flight Mass Spectrometry and Its Application to Single-Particle Detection
Gundlach-Graham, Alexander
Hendriks, Lyndsey
Mehrabi, Kamyar
Guenther, Detlef
ANALYTICAL CHEMISTRY, 2018, 90 (20) : 11847 - 11855
[50] Classification of the source of treatment deviation in proton therapy using prompt-gamma imaging information
Khamfongkhruea, Chirasak
Berthold, Jonathan
Janssens, Guillaume
Petzoldt, Johannes
Smeets, Julien
Pausch, Guntram
Richter, Christian
MEDICAL PHYSICS, 2020, 47 (10) : 5102 - 5111

← 1 2 3 4 5 →