A Single-Particle Trigger for Time-of-Flight Measurements in Prompt-Gamma Imaging

被引：8

作者：

Martins, Paulo Magalhaes ^{[1
,2
]}

Dal Bello, Riccardo ^{[1
,3
]}

Seimetz, Michael ^{[4
]}

Hermann, German ^{[5
]}

Kihm, Thomas ^{[5
]}

Seco, Joao ^{[1
,3
]}

机构：

[1] German Canc Res Ctr, Heidelberg, Germany

[2] Univ Lisbon, Inst Biofis & Engn Biomed, Fac Ciencias, Lisbon, Portugal

[3] Heidelberg Univ, Dept Phys & Astron, Heidelberg, Germany

[4] Univ Politecn Valencia, Inst Instrumentac Imagen Mol I3M, CSIC, Valencia, Spain

[5] Max Planck Inst Nucl Phys, Heidelberg, Germany

来源：

FRONTIERS IN PHYSICS | 2020年 / 8卷

关键词：

prompt-gamma; particle tracking; scintillating fibers; ion-beam therapy; synchrotrons; PROTON RANGE VERIFICATION; PLASTIC SCINTILLATION DETECTORS; ENERGY BEAM DOSIMETRY; RANDOM COINCIDENCES; PET MEASUREMENTS; SLIT CAMERA; PHOTON; SYSTEM; RAYS;

D O I：

10.3389/fphy.2020.00169

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Tracking of single particles accelerated by synchrotrons is a subject that crosses several physics fields. The high clinical intensities used in particle therapy that can exceed 10(9)p/s make this task very challenging. The tracking of the arrival time of single particles in the ion beam is fundamental for the verification of the particle range and dose delivered to the patient. We present a prototype made of scintillating fibers which has been used to provide time-of-flight (TOF) information for three beam species currently accelerated at the Heidelberg Ion-Beam Therapy Center (HIT). We have demonstrated a time-tracker for a prompt-gamma spectroscopy system that allows for a background TOF rejection with a sub-nanosecond time resolution.

引用

页数：13

共 50 条

[1] Prompt-gamma imaging in particle therapy
Pinto, Marco
EUROPEAN PHYSICAL JOURNAL PLUS, 2024, 139 (10):
[2] Editorial: Prompt-gamma imaging in particle therapy
Magalhaes Martins, Paulo
Draeger, Emily
Wronska, Aleksandra
FRONTIERS IN PHYSICS, 2024, 12
[3] SINGLE-PARTICLE CHARACTERIZATION BY TIME-OF-FLIGHT MASS-SPECTROMETRY
REENTS, WD
DOWNEY, SW
EMERSON, AB
MUJSCE, AM
MULLER, AJ
SICONOLFI, DJ
SINCLAIR, JD
SWANSON, AG
AEROSOL SCIENCE AND TECHNOLOGY, 1995, 23 (03) : 263 - 270
[4] A time-of-flight-based reconstruction for real-time prompt-gamma imaging in proton therapy
Jacquet, Maxime
Marcatili, Sara
Gallin-Martel, Marie-Laure
Bouly, Jean-Luc
Boursier, Yannick
Dauvergne, Denis
Dupont, Mathieu
Gallin-Martel, Laurent
Herault, Joel
Letang, Jean-Michel
Maneval, Daniel
Morel, Christian
Muraz, Jean-Francois
Testa, Etienne
PHYSICS IN MEDICINE AND BIOLOGY, 2021, 66 (13):
[5] Optimisation of a Prompt-Gamma Slit Imaging System for Particle Beam Range Verification
Vella, A.
Van den Heuvel, F.
RADIOTHERAPY AND ONCOLOGY, 2020, 152 : S122 - S122
[6] Organic particle types by single-particle measurements using a time-of-flight aerosol mass spectrometer coupled with a light scattering module
Liu, S.
Russell, L. M.
Sueper, D. T.
Onasch, T. B.
ATMOSPHERIC MEASUREMENT TECHNIQUES, 2013, 6 (02) : 187 - 197
[7] Single-particle correlated time-of-flight velocimeter for remote wind-speed measurement
Bartlett, K. G.
She, C. Y.
OPTICS LETTERS, 1977, 1 (05) : 175 - 177
[8] Single-Particle Time-of-Flight Mass Spectrometry Utilizing a Femtosecond Desorption and Ionization Laser
Zawadowicz, Maria A.
Abdelmonem, Ahmed
Mohr, Claudia
Saathoff, Harald
Froyd, Karl D.
Murphy, Daniel M.
Leisner, Thomas, I
Cziczo, Daniel J.
ANALYTICAL CHEMISTRY, 2015, 87 (24) : 12221 - 12229
[9] COHN analysis: Body composition measurements based on the associated particle imaging and prompt-gamma neutron activation analysis techniques
Ellis, K. J.
Shypailo, R. J.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2008, 276 (01) : 79 - 83
[10] COHN analysis: Body composition measurements based on the associated particle imaging and prompt-gamma neutron activation analysis techniques
K. J. Ellis
R. J. Shypailo
Journal of Radioanalytical and Nuclear Chemistry, 2008, 276 : 79 - 83

← 1 2 3 4 5 →