Sequence analysis and distribution of two new human cathepsin L splice variants

被引：24
|
作者：
Rescheleit, DK [1 ]
Rommerskirch, WJ [1 ]
Wiederanders, B [1 ]
机构：
[1] UNIV JENA KLINIKUM,INST BIOCHEM,D-07740 JENA,GERMANY
来源：
FEBS LETTERS | 1996年 / 394卷 / 03期
关键词：
cathepsin L; alternative splicing; 5' UTR stem loop; post-transcriptional control; tumor;
D O I：
10.1016/0014-5793(96)00986-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Despite elevated cathepsin L mRNA levels in kidney tumors, cathepsin L protein/activity was scarcely detectable in these tumors. As a possible reason, we detected two new splice variants of human cathepsin L mRNAs not identical to those previously reported. Besides the normal 'full-length' mRNA (hCATL-A) there is one form lacking 27 nucleotides (hCATL-A I) and another form lacking 90 nucleotides (hCATL-A II) in exon I. The splice variants do not influence the amino acid sequence of the translational product. hCATL-A and hCATL-A I probably form a secondary structure at the 5' non-coding sequence not present in hCATL-A II.
引用
收藏
页码：345 / 348
页数：4
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