Sequence analysis and distribution of two new human cathepsin L splice variants

被引：24

作者：

Rescheleit, DK ^{[1
]}

Rommerskirch, WJ ^{[1
]}

Wiederanders, B ^{[1
]}

机构：

[1] UNIV JENA KLINIKUM,INST BIOCHEM,D-07740 JENA,GERMANY

来源：

FEBS LETTERS | 1996年 / 394卷 / 03期

关键词：

cathepsin L; alternative splicing; 5' UTR stem loop; post-transcriptional control; tumor;

D O I：

10.1016/0014-5793(96)00986-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite elevated cathepsin L mRNA levels in kidney tumors, cathepsin L protein/activity was scarcely detectable in these tumors. As a possible reason, we detected two new splice variants of human cathepsin L mRNAs not identical to those previously reported. Besides the normal 'full-length' mRNA (hCATL-A) there is one form lacking 27 nucleotides (hCATL-A I) and another form lacking 90 nucleotides (hCATL-A II) in exon I. The splice variants do not influence the amino acid sequence of the translational product. hCATL-A and hCATL-A I probably form a secondary structure at the 5' non-coding sequence not present in hCATL-A II.

引用

页码：345 / 348

页数：4

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