Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors

被引：21

作者：

Mittapalli, Gopi Kumar ^{[1
]}

Jackson, Andrew ^{[1
]}

Zhao, Fang ^{[1
]}

Lee, Haekyung ^{[1
]}

Chow, Stephine ^{[1
]}

McKelvy, Jeffrey ^{[1
]}

Wong-Staal, Flossie ^{[1
]}

Macdonald, James E. ^{[1
]}

机构：

[1] iTherX Pharmaceut Inc, San Diego, CA 92191 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 22期

关键词：

Hepatitis C Virus; Entry inhibitors; Tetrahydrocarbazoles; HCVcc; Pharmacokinetics; HCV ENTRY; ANTIVIRAL THERAPY; INFECTION; RECEPTOR; CULTURE; TARGETS; DRUGS;

D O I：

10.1016/j.bmcl.2011.09.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel, highly potent small molecule HCV entry inhibitors are reported. The SAR exploration of a hit molecule identified from screening of a compound library led to the identification of highly potent compounds with IC50 values of <5 nM in the tissue culture HCV infectious assay. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6852 / 6855

页数：4

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