Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors

被引：21
|
作者：
Mittapalli, Gopi Kumar [1 ]
Jackson, Andrew [1 ]
Zhao, Fang [1 ]
Lee, Haekyung [1 ]
Chow, Stephine [1 ]
McKelvy, Jeffrey [1 ]
Wong-Staal, Flossie [1 ]
Macdonald, James E. [1 ]
机构：
[1] iTherX Pharmaceut Inc, San Diego, CA 92191 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 22期
关键词：
Hepatitis C Virus; Entry inhibitors; Tetrahydrocarbazoles; HCVcc; Pharmacokinetics; HCV ENTRY; ANTIVIRAL THERAPY; INFECTION; RECEPTOR; CULTURE; TARGETS; DRUGS;
D O I：
10.1016/j.bmcl.2011.09.019
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel, highly potent small molecule HCV entry inhibitors are reported. The SAR exploration of a hit molecule identified from screening of a compound library led to the identification of highly potent compounds with IC50 values of <5 nM in the tissue culture HCV infectious assay. (C) 2011 Elsevier Ltd. All rights reserved.
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收藏
页码：6852 / 6855
页数：4
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