Challenges of Ionizing Radiation in Tumor Treatment and Role of Angiogenesis

被引：0

作者：

Das, Subir Kumar ^{[1
,2
]}

机构：

[1] WBUHS, Coll Med, Dept Biochem, Kalyani 741235, W Bengal, India

[2] WBUHS, JNM Hosp, Kalyani 741235, W Bengal, India

来源：

INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS | 2014年 / 51卷 / 06期

关键词：

Angiogenesis; Hypoxia; Ionizing radiation; Signaling mechanism; VEGF; ANTIANGIOGENIC THERAPY; CANCER-TREATMENT; UP-REGULATION; RADIOTHERAPY; PATHWAYS; CELLS; MALIGNANCIES; IRRADIATION; INHIBITION; STRESS;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ionizing radiation is a non-specific, but most widely used therapeutic method for cancer treatment. However, a minor fraction of tumor cell population manages to survive after radiation. Radiation efficacy depends on adequate oxygen supply. Rapid growing tumors cause hypoxia that upregulates many pro-survival pathways. At clinical doses, radiation activates inflammatory pathways and causes oxidative stress that plays a positive role during angiogenesis. Selective targeting of signaling mechanisms may radiosensitize tumors.

引用

页码：527 / 530

页数：4

共 50 条

[21] Wastewater treatment with ionizing radiation
Wojnarovits, Laszlo
Takacs, Erzsebet
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2017, 311 (02) : 973 - 981
[22] Treatment of food with ionizing radiation
Nooitgedagt, AJ
TIJDSCHRIFT VOOR DIERGENEESKUNDE, 1997, 122 (06) : 158 - 163
[23] Wastewater treatment with ionizing radiation
László Wojnárovits
Erzsébet Takács
Journal of Radioanalytical and Nuclear Chemistry, 2017, 311 : 973 - 981
[24] Low Doses of Ionizing Radiation Induce Angiogenesis: Therapeutic Implications
Marques, F. G.
Ferreira, J.
Cardina, C.
Poli, E.
Malaquias, J.
Pina, F.
Mendes de Almeida, J. C.
Mareel, M.
Constantino Rosa Santos, S.
JOURNAL OF VASCULAR RESEARCH, 2017, 54 : 16 - 16
[25] Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study
Oliver Riesterer
Christoph Oehler-Jänne
Wolfram Jochum
Angela Broggini-Tenzer
Van Vuong
Martin Pruschy
Radiation Oncology, 6
[26] Digital subtraction angiography and computer assisted image analysis for the evaluation of the antiangiogenetic effect of ionizing radiation on tumor angiogenesis
Dimitrios Siablis
Evangelos N. Liatsikos
Dimitrios Karnabatidis
George C. Kagadis
George C. Sakelaropoulos
John Maroulis
Dimitrios Kardamakis
Anastasios Athanassopoulos
Petros Perimenis
George Nikiforidis
George A. Barbalias
International Urology and Nephrology, 2006, 38 : 407 - 411
[27] Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study
Riesterer, Oliver
Oehler-Jaenne, Christoph
Jochum, Wolfram
Broggini-Tenzer, Angela
Vuong, Van
Pruschy, Martin
RADIATION ONCOLOGY, 2011, 6
[28] Engaging human tumor microvascular endothelium to improve ionizing radiation outcomes in solid tumor treatment.
Lewin, S. N.
Barakat, R. R.
Haimovitz-Friedman, A.
Kolesnick, R.
Fuks, Z.
Poynor, E. A.
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (18) : 564S - 564S
[29] In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment
Landuyt, W
Ahmed, B
Nuyts, S
Theys, J
de Beeck, MO
Rijnders, A
Anné, J
van Oosterom, A
Van den Bogaert, W
Lambin, P
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 49 (02): : 443 - 450
[30] Role of Ionizing Radiation in Neurodegenerative Diseases
Sharma, Neel K.
Sharma, Rupali
Mathur, Deepali
Sharad, Shashwat
Minhas, Gillipsie
Bhatia, Kulsajan
Anand, Akshay
Ghosh, Sanchita P.
FRONTIERS IN AGING NEUROSCIENCE, 2018, 10

← 1 2 3 4 5 →