Challenges of Ionizing Radiation in Tumor Treatment and Role of Angiogenesis

被引：0
|
作者：
Das, Subir Kumar [1 ,2 ]
机构：
[1] WBUHS, Coll Med, Dept Biochem, Kalyani 741235, W Bengal, India
[2] WBUHS, JNM Hosp, Kalyani 741235, W Bengal, India
来源：
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS | 2014年 / 51卷 / 06期
关键词：
Angiogenesis; Hypoxia; Ionizing radiation; Signaling mechanism; VEGF; ANTIANGIOGENIC THERAPY; CANCER-TREATMENT; UP-REGULATION; RADIOTHERAPY; PATHWAYS; CELLS; MALIGNANCIES; IRRADIATION; INHIBITION; STRESS;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ionizing radiation is a non-specific, but most widely used therapeutic method for cancer treatment. However, a minor fraction of tumor cell population manages to survive after radiation. Radiation efficacy depends on adequate oxygen supply. Rapid growing tumors cause hypoxia that upregulates many pro-survival pathways. At clinical doses, radiation activates inflammatory pathways and causes oxidative stress that plays a positive role during angiogenesis. Selective targeting of signaling mechanisms may radiosensitize tumors.
引用
收藏
页码：527 / 530
页数：4
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