Activation of Alternative Lengthening of Telomeres (ALT) in Primary Pancreatic Neuroendocrine Tumors Serves as Both a Prognostic Biomarker and Potential Therapeutic Target

被引:0
|
作者
Rizzo, Anthony [1 ]
Brosnan-Cashman, Jacqueline [1 ]
Graham, Mindy [1 ]
Hruban, Ralph [1 ]
Heaphy, Christopher [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:353 / 353
页数:1
相关论文
共 46 条
  • [21] Alternative Lengthening of Telomeres and Loss of ATRX/DAXX Can Be Reliably Detected in Fine Needle Aspirates of Pancreatic Neuroendocrine Tumors
    Allison, Derek
    Heaphy, Christopher M.
    Graham, Mindy K.
    Charu, Vivek
    Hruban, Ralph H.
    VandenBussche, Christopher
    MODERN PATHOLOGY, 2017, 30 : 441A - 441A
  • [22] Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors
    Singhi, Aatur D.
    Liu, Ta-Chiang
    Roncaioli, Justin L.
    Cao, Dengfeng
    Zeh, Herbert J.
    Zureikat, Amer H.
    Tsung, Allan
    Marsh, J. Wallis
    Lee, Kenneth K.
    Hogg, Melissa E.
    Bahary, Nathan
    Brand, Randall E.
    McGrath, Kevin M.
    Slivka, Adam
    Cressman, Kristi L.
    Fuhrer, Kimberly
    O'Sullivan, Roderick J.
    CLINICAL CANCER RESEARCH, 2017, 23 (02) : 600 - 609
  • [23] Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients With Pancreatic Neuroendocrine Tumors
    Singhi, A. D.
    Liu, T. -C.
    Roncaioli, J. L.
    Zeh, H. J.
    Zureikat, A. H.
    Tsung, A.
    Marsh, J. W.
    Lee, K. K.
    Hogg, M. E.
    Bahary, N.
    Brand, R. E.
    McGrath, K.
    Slivka, A.
    Cressman, K. L.
    Fuhrer, K.
    O'Sullivan, R. J.
    PANCREAS, 2016, 45 (10) : 1539 - 1539
  • [24] Aberrant expression of VASP serves as a potential prognostic biomarker and therapeutic target for oral squamous cell carcinoma
    Gopalakrishnan, Karpakavinayakam
    Kannan, Balachander
    Pandi, Chandra
    Pandi, Anitha
    Ramasubramanian, Abilasha
    Jayaseelan, Vijayashree Priyadharsini
    Arumugam, Paramasivam
    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 2024, 138 (03): : 391 - 402
  • [25] Glucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres)
    Mattiolo, Paola
    Bevere, Michele
    Mafficini, Andrea
    Verschuur, Anna Vera D.
    Calicchia, Martina
    Hackeng, Wenzel M.
    Simbolo, Michele
    Paiella, Salvatore
    Dreijerink, Koen M. A.
    Landoni, Luca
    Pedron, Serena
    Cingarlini, Sara
    Salvia, Roberto
    Milella, Michele
    Lawlor, Rita T.
    Valk, Gerlof D.
    Vriens, Menno R.
    Scarpa, Aldo
    Brosens, Lodewijk A.
    Luchini, Claudio
    ENDOCRINE PATHOLOGY, 2024, 35 (04) : 354 - 361
  • [26] COL5A3: A prognostic biomarker and potential therapeutic target in pancreatic cancer
    Li, Yongjie
    Zeng, Min
    Wang, Ting
    Jiang, Feng
    Li, Chengjian
    MCB Molecular and Cellular Biomechanics, 2024, 21 (04):
  • [27] Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in nonfunctional pancreatic neuroendocrine tumors
    Mastrosimini, M. G.
    Manfrin, E.
    Remo, A.
    de Bellis, M.
    Pedron, S.
    Luchini, C.
    Brunelli, M.
    Ammendola, S.
    Pea, A.
    Landoni, L.
    Scarpa, A.
    Crino, S. F.
    JOURNAL OF NEUROENDOCRINOLOGY, 2023, 35 : 124 - 124
  • [28] Alternative lengthening of telomeres and Ki-67 proliferation index provide complementary information on recurrence risk after resection of pancreatic neuroendocrine tumors
    Gudmundsdottir, Hallbera
    Graham, Rondell P.
    Greipp, Patricia T.
    Habermann, Elizabeth B.
    Knudson, Ryan A.
    Brandt, Carrie A.
    Starlinger, Patrick
    Thiels, Cornelius A.
    Warner, Susanne G.
    Smoot, Rory L.
    Truty, Mark J.
    Kendrick, Michael L.
    Nagorney, David M.
    Cleary, Sean P.
    Halfdanarson, Thorvardur R.
    JOURNAL OF NEUROENDOCRINOLOGY, 2025,
  • [29] CD39 (ENTPD1) in tumors: a potential therapeutic target and prognostic biomarker
    Li, Cuicui
    Zhang, Litian
    Jin, Qiqi
    Jiang, Haoyun
    Wu, Chongyang
    BIOMARKERS IN MEDICINE, 2023, 17 (12) : 563 - 576
  • [30] B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors
    Petar Rasic
    Maja Jovanovic-Tucovic
    Marija Jeremic
    Slavisa M Djuricic
    Zorica V Vasiljevic
    Maja Milickovic
    Djordje Savic
    World Journal of Gastrointestinal Oncology, 2021, 13 (08) : 799 - 821