Copper-catalyzed [4+2] oxidative annulation of α,β-unsaturated ketoxime acetates with ethyl trifluoropyruvate

被引：9

作者：

Yan, Huan ^{[1
]}

Xu, Gaochen ^{[1
]}

Gu, Meng ^{[1
]}

Zhang, Sai ^{[1
]}

Wu, Qinghuan ^{[1
]}

Meng, Jingjing ^{[1
]}

Zhu, Ning ^{[1
]}

Fang, Zheng ^{[1
]}

Duan, Jindian ^{[1
]}

Guo, Kai ^{[1
]}

机构：

[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, 30 Puzhu Rd S, Nanjing 211816, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 47期

基金：

中国国家自然科学基金;

关键词：

TETHERED ACYL OXIMES; SYMMETRICAL PYRIDINES; CYCLIZATION; ESTERS; ACCESS; 2H-1,3-OXAZINES; FUNCTIONALIZATION; CYCLOADDITION; CONSTRUCTION; CARBOXYLATES;

D O I：

10.1039/d2cc01573k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel route for tandem C-N/C-O formation via copper-catalyzed [4+2] oxidative annulation of alpha,beta-unsaturated ketoxime acetates with ethyl trifluoropyruvate to synthesize valuable trifluoromethyl-containing 2H-1,3-oxazines in moderate to good yields is developed. This procedure represents the first [4+2] oxidative annulation of oxime derivatives with activated C=O bonds and provides an alternative route towards functionalized 2H-1,3-oxazines.

引用

页码：6757 / 6760

页数：4

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