iMarmot: an integrative platform for comparative and functional genomics of marmots

被引:4
|
作者
Liu, Baoning [1 ,2 ]
Bai, Liang [1 ,2 ]
Yu, Qingqing [1 ,2 ]
Hu, Fang [1 ,2 ]
Wu, Jing [1 ,3 ]
Zhao, Sihai [1 ,2 ]
Wang, Rong [1 ,2 ]
Wang, Weirong [1 ,2 ]
Tao, Yuanqing [4 ]
Fan, Jianglin [5 ]
Liu, Enqi [1 ,2 ]
机构
[1] Xi An Jiao Tong Univ, Lab Anim Ctr, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Res Inst Atherosclerot Dis, Cardiovasc Res Ctr, Xian 710061, Shaanxi, Peoples R China
[3] Ningxia Med Univ, Lab Anim Ctr, Yinchuan 750004, Gansu, Peoples R China
[4] Qinghai Inst Endem Dis Prevent & Control, Xining 811602, Qinghai, Peoples R China
[5] Univ Yamanashi, Interdisciplinary Grad Sch Med, Dept Mol Pathol, Fac Med, Yamanashi 4093898, Japan
基金
中国博士后科学基金;
关键词
NATURAL FOCUS; ANNOTATION; RECONSTRUCTION; TRANSCRIPTOME; ALIGNMENT; RODENTIA; PLAGUE;
D O I
10.1186/s12864-020-6697-7
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background Marmots are large Holarctic rodents with unique biological features, making them potential animal models in various research fields. Due to the rapid accumulation of the genetic data in marmots, a highly integrative database is urgent needed. Description iMarmot is freely available on the web at and currently contains the biological information of 14 marmots, genomic sequence of 6 marmots, syntenic relationship and orthologs among 3 marmots, and expression profiles of several hibernators and plague hosts. To assist with the genomic and transcriptomic analysis, we also integrated a set of analysis and visualization tools, such as KEGG or GO enrichment analysis, PCA, Blast, Muscle, GeneWise, Lastz, and JBrowse. Particularly, one DEGs (differentially expressed genes) module has been implemented in this database to visualize the gene expression changes in hibernators and plague hosts. Conclusion This database will provide comprehensive information and analysis platform for researchers interested in understanding the biological features of marmots.
引用
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页数:8
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