Effect of UV irradiation on the physico-chemical properties of iron crosslinked collagen

被引：17

作者：

Fathima, Nishter Nishad ^{[1
]}

Rao, Jonnalagadda Raghava ^{[1
]}

Nair, Balachandran Unni ^{[1
]}

机构：

[1] CSIR, Cent Leather Res Inst, Chem Lab, Madras 600020, Tamil Nadu, India

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2011年 / 105卷 / 03期

关键词：

Collagen; UV radiation; Circular dichroism (CD); Fluorescence; Absorption; Iron; TANNED COLLAGEN; LINKING; RADIATION; DEGRADATION; ELASTIN; TISSUE; WATER; SKIN;

D O I：

10.1016/j.jphotobiol.2011.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Collagen is the main component of connective tissue and finds immense applications as a biomaterial. In this study, effect of UV irradiation on collagen crosslinked with iron has been carried out. The physical and optical properties of crosslinked collagen affected by UV irradiation were analyzed using electrospectral and fluorescence studies. The electronic spectral studies showed that the photoproducts formed on UV radiation decrease in the presence of iron. Circular dichroic studies revealed that the conformational changes brought about in the protein due to UV irradiation have been reduced owing to the crosslinking with iron. However, prolonged irradiation does bring about conformational changes to the protein. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：203 / 206

页数：4

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