Survey of reverse transcriptase from the heterosexual epidemic of human immunodeficiency virus type 1 CRF01_AE in Thailand from 1990 to 2000

被引：6
|
作者：
Sirivichayakul, S
Chantratita, W
Sutthent, R
Ruxrungtham, K
Phanuphak, P
Oelrichs, RB
机构：
[1] Chulalongkorn Univ, Dept Med, Div Clin Immunol & Allergy, Bangkok 10330, Thailand
[2] Ramathibodi Hosp, Fac Med, Dept Pathol, Bangkok 10400, Thailand
[3] Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok 10700, Thailand
[4] Thai Red Cross AIDS Res Ctr, Bangkok 10330, Thailand
[5] Macfarlane Burnet Ctr Med Res, Fairfield, Vic 3078, Australia
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2001年 / 17卷 / 11期
关键词：
D O I：
10.1089/088922201300343762
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Genetic diversity of the HIV-1 envelope gene has shown a steady increase over time in the Thai and other regional epidemics. A serial survey of subtype CRF01_AE polymerase gene (RT) diversity in Thailand was performed, using 48 novel and 15 reported sequences covering the period 1990-2000. These sequences were gathered from individuals whose sole risk factor for infection was heterosexual contact. By contrast to envelope, diversity was low and, despite a 40% increase early in the epidemic, has remained static since 1996. These results indicate that epidemic HIV-1 may be constrained within defined limits of genetic diversity at least in some genomic regions.
引用
收藏
页码：1077 / 1081
页数：5
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