Oral Hypoglycemic Agents Added to Insulin Monotherapy for Type 2 Diabetes

被引：2

作者：

Vos, Rimke C. ^{[1
]}

Rutten, Guy E. H. M. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Gen Practice, Julius Ctr Hlth Sci & Primary Care, Huispostnr STR 6-131,POB 85500, NL-3508 GA Utrecht, Netherlands

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2017年 / 318卷 / 15期

关键词：

D O I：

10.1001/jama.2017.13463

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CLINICAL QUESTION Among patients with type 2 diabetes mellitus who do not achieve optimal glycemic control with insulin monotherapy, is the addition of oral hypoglycemic agents associated with benefits (measured by lowering of hemoglobin A(1c)) or adverse effects? BOTTOM LINE Adding a sulfonylurea to insulin was associated with more hypoglycemic events compared with insulin alone, but this association was not observed for metformin. Adding a sulfonylurea or metformin to insulin was associated with a decrease in hemoglobin A1c of approximately 1.0%.

引用

页码：1489 / 1490

页数：2

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