Keratinocyte Growth Factor-Based Strategies for Wound Re-Epithelialization

被引:0
|
作者
Bartolo, Ines [1 ,2 ]
Reis, Rui L. [1 ,2 ]
Marques, Alexandra P. [1 ,2 ]
Cerqueira, Mariana T. [1 ,2 ]
机构
[1] Univ Minho, I3Bs Res Inst Biomat Biodegradables & Biomimet, European Inst Excellence Tissue Engn & Regenerat, 3Bs Res Grp, P-4805017 Barco, Guimaraes, Portugal
[2] ICVS 3Bs PT Govt Associate Lab, Guimaraes, Portugal
关键词
skin; growth factor; re-epithelialization; delivery; FACTOR GENE-EXPRESSION; STIMULATES MIGRATION; DRUG-DELIVERY; IN-VITRO; SKIN; NANOPARTICLES; DIFFERENTIATION; PROLIFERATION; ULCERS; EPITHELIALIZATION;
D O I
10.1089/ten.teb.2021.0030
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Wound re-epithelialization is a dynamic process that comprises the formation of new epithelium through an active signaling network between several growth factors (GFs) and various cell types. The main players are keratinocytes (KCs) that migrate from the wound edges over the wound bed to restore the epidermal barrier. One of the most important molecules involved in the re-epithelialization process is keratinocyte growth factor (KGF), a central player on promoting both migration and proliferation of KCs. Stromal cells, such as dermal fibroblasts, are the main producers of this factor, acting on KCs through paracrine signaling. Multiple therapeutic strategies to deliver KGF have been proposed to boost wound healing by targeting re-epithelialization. Different approaches have been explored to attain that purpose, such as topical application of this factor, controlled release of KGF from different biomaterials (hydrogels, nanoparticles, and membranes), and also gene delivery techniques. Among these strategies, KGF release via biomaterials- and genetic-based strategies shows great effectiveness in maintaining sustained KGF levels at the wound site, which is reflected in an efficient wound closure. Under this scope, this review aims not only to elucidate the potential of KGF in wound re-epithelialization but also to describe the underlying mechanism of action and further explore the therapeutic approaches using this GF.
引用
收藏
页码:665 / 676
页数:12
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