Design, synthesis, and molecular modeling of novel 6-substituted pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic agents

被引:0
|
作者
Islam, Farhana [1 ]
Seybert, David [2 ]
Gangjee, Aleem [1 ]
机构
[1] Duquesne Univ, Grad Sch Pharmaceut Sci, Div Med Chem, Pittsburgh, PA 15219 USA
[2] Duquesne Univ, Bayer Sch Nat & Environm Sci, Dept Chem & Biochem, Pittsburgh, PA 15219 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
227
引用
收藏
页数:1
相关论文
共 50 条
  • [31] Synthesis of some new pyrido [2,3-d] pyrimidines and their ribofuranosides as potential therapeutic agents
    Garg, Reshu
    Kumar, Neeraj
    Kumar, Naresh
    Mishra, A. K.
    Yadav, Ashok K.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 16 (01) : 25 - 28
  • [32] Design, synthesis and biological evaluation of 2,4-diamino-6-methyl-5-substitutedpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors
    Gangjee, A
    Jain, HD
    Queener, SF
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 42 (04) : 589 - 594
  • [33] Synthesis of novel thioxoderivatives of pyrido[2,3-d]pyrimidines and their nucleosides as possible anticancer agents
    Sharma, SK
    Swati
    Yadav, AK
    Prakash, L
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1996, 112 (1-4): : 109 - 114
  • [34] MEDI 138-2, 4-Diamino-6-arylthino[2,3-d]pyrimidines as potential dihydrofolate reductase inhibitors
    Gangjee, Aleem
    Zhou, Xilin
    Kisliuk, Roy L.
    Queener, Sherry F.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232
  • [35] Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents
    Gangjee, A
    Adair, OO
    Queener, SF
    JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (23) : 5074 - 5082
  • [36] Synthesis of novel condensed pyridines and pyrido[2,3-d]pyrimidines
    E. G. Paronikyan
    A. S. Noravyan
    A. S. Harutunyan
    Chemistry of Heterocyclic Compounds, 2010, 46 : 987 - 990
  • [37] SYNTHESIS OF NOVEL CONDENSED PYRIDINES AND PYRIDO[2,3-d]PYRIMIDINES
    Paronikyan, E. G.
    Noravyan, A. S.
    Harutunyan, A. S.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2010, 46 (08) : 987 - 990
  • [38] Novel 6-methylthio bridged 2,4-diaminopyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
    Gangjee, A
    Adair, O
    Queener, SF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 214 : 168 - MEDI
  • [39] Synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines with substituted nitrogen bridges as targeted antifolates
    Gangjee, Aleem
    Golani, Lalit
    Dann, Charles
    Deis, Siobhan
    Wallace-Povirk, Andrianne
    Hou, Zhanjun
    Matherly, Larry
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [40] 2-amino-4-methylpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
    Gangjee, A
    Yu, JM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U302 - U302