Endothelial nitric oxide synthase gene polymorphisms and the risk ofischemic stroke in young Chinese population

被引：0
|
作者：
Shi, Congning [1 ]
Wang, Yajie [1 ]
Zhou, Yali [1 ]
Kang, Xixiong [1 ]
机构：
[1] Capital Med Univ, Affiliated Hosp 5, Beijing Tiantan Hosp, Dept Exp & Diagnosis Ctr, Beijing 100050, Peoples R China
来源：
PROGRESS ON POST-GENOME TECHNOLOGIES | 2007年
关键词：
eNOS; SNP; ischemic stroke; young Chinese population;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Genetic influences are important in multifactorial ischemic stroke and may act via endothelial dysfunction. Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) is a key mediator of endothelial function. We determined the role of 3 potentially functional eNOS polymorphisms (T-786C, intron 4ab, G894T) located toward the 5 flanking end of the gene as risk factors for ischemic stroke in young Chinese population. 100 patients with ischemic stroke and 100 controls were studied. Genotypes were determined through polymerase chain reaction with or without restriction fragment digestion. The intron 4a variant was protective against ischemic stroke in young Chinese population.
引用
收藏
页码：318 / 319
页数：2
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