Targeting Pyruvate Kinase M2 As a Novel Therapeutic Strategy Against Liver Fibrosis and Hepatocellular Carcinoma

被引：0
|
作者：
Zheng, Dandan [1 ]
Lin, Zelong [1 ,2 ]
Hu, Kaishun [3 ]
Lan, Tian [4 ]
Holmes, Jacinta A. [5 ,6 ,7 ]
Song, Zhenghui [2 ,8 ]
He, Lu [1 ]
Jiang, Yuchuan [1 ]
Chen, Peng [1 ,2 ]
Tu, Mengxian [1 ]
Chen, Hengxing [3 ]
Hu, Qiaoting [1 ]
Qu, Chen [1 ,2 ]
Lin, Wenyu [5 ,6 ,7 ]
Li, Aimin [2 ,8 ]
Chung, Raymond T. [5 ,6 ,7 ]
Hong, Jian [1 ,2 ]
机构：
[1] Southern Med Univ, Integrated Hosp Tradit Chinese Med, Dept Abdominal Surg, Guangzhou, Guangdong, Peoples R China
[2] Southern Med Univ, Canc Ctr, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Guangdong, Peoples R China
[4] Guangdong Pharmaceut Univ, Guangzhou, Guangdong, Peoples R China
[5] Massachusetts Gen Hosp, Liver Ctr, Boston, MA 02114 USA
[6] Massachusetts Gen Hosp, Gastrointestinal Div, Boston, MA 02114 USA
[7] Harvard Med Sch, Boston, MA USA
[8] Southern Med Univ, Integrated Hosp Tradit Chinese Med, Dept Hepatol, Guangzhou, Guangdong, Peoples R China
来源：
HEPATOLOGY | 2018年 / 68卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
1120
引用
收藏
页码：646A / 647A
页数：2
相关论文
共 50 条
  • [1] PYRUVATE KINASE M2 TETRAMERIZATION PROTECTS AGAINST HEPATIC STELLATE CELL ACTIVITY, LIVER FIBROSIS, AND HEPATOCELLULAR CARCINOMA
    Zheng, Dandan
    Qu, Chen
    Hu, Kaishun
    Yuan, Hui
    He, Lu
    Chen, Peng
    Jiang, Yuchuan, Jr.
    Li, Jinying
    Tu, Mengxian
    Lin, Lehang
    Chen, Hengxing
    Wu, Ziqing
    Lin, Wenyu
    Chung, Raymond T.
    Hong, Jian
    HEPATOLOGY, 2019, 70 : 53A - 54A
  • [2] Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis
    Zheng, Dandan
    Jiang, Yuchuan
    Qu, Chen
    Yuan, Hui
    Hu, Kaishun
    He, Lu
    Chen, Peng
    Li, Jinying
    Tu, Mengxian
    Lin, Lehang
    Chen, Hengxing
    Lin, Zelong
    Lin, Wenyu
    Fan, Jun
    Cheng, Guohua
    Hong, Jian
    AMERICAN JOURNAL OF PATHOLOGY, 2020, 190 (11): : 2267 - 2281
  • [3] Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis
    Nayak, Manasa K.
    Ghatge, Madankumar
    Dhanesha, Nirav
    Flora, Gagan D.
    Jain, Manish
    Rodriguez, Omar
    Markan, Kathleen
    Potthoff, Mathhhew
    Lentz, Steven R.
    Chauhan, Anil K.
    BLOOD, 2019, 134
  • [4] The Role of Pyruvate Kinase M2 Posttranslational Modification in the Occurrence and Development of Hepatocellular Carcinoma
    Zhao, Chunlian
    Wan, Qi
    Zhao, Rui
    CELL BIOCHEMISTRY AND FUNCTION, 2024, 42 (07)
  • [5] Progress of Pyruvate Kinase M2 in Hepatocellular Carcinoma-Associated Signaling Pathway
    Wan, Qi
    Zhao, Chunlian
    Zhao, Rui
    TISSUE ENGINEERING PART C-METHODS, 2025, 31 (03) : 101 - 107
  • [6] Targeting pyruvate kinase M2 for the treatment of kidney disease
    Chen, Dan-Qian
    Han, Jin
    Liu, Hui
    Feng, Kai
    Li, Ping
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [7] Pyruvate Kinase M2: a novel regulator of adipogenesis
    Dowker, Presley D.
    Demeter, Jenna B.
    Bettaieb, Ahmed
    FASEB JOURNAL, 2022, 36
  • [8] The role of pyruvate kinase M2 in anticancer therapeutic treatments
    Su, Qiongli
    Luo, Shengping
    Tan, Qiuhong
    Deng, Jun
    Zhou, Sichun
    Peng, Mei
    Tao, Ting
    Yang, Xiaoping
    ONCOLOGY LETTERS, 2019, 18 (06) : 5663 - 5672
  • [9] Role of Pyruvate Kinase M2 and Its Potential Pathogenic Mechanisms in Human Hepatocellular Carcinoma
    Zhao, Rui
    Li, Lei
    Dong, Li
    Zhang, Lingyi
    Yang, Jinbo
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2018, 8 (12) : 1743 - 1748
  • [10] miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma
    Xu, Zhi
    Liu, Angela
    Lee, Nikki
    Chen, Jinfei
    Luk, John M.
    CANCER RESEARCH, 2014, 74 (19)
12345