Prognostic Value of Hematological Parameters in Locally Advanced Cervical Cancer Patients Treated With Concurrent Chemoradiotherapy

被引：25
|
作者：
Lee, Hyun Jung [1 ,2 ]
Kim, Jong Mi [1 ,2 ]
Chin, Yoo Jeong [1 ,2 ]
Chong, Gun Oh [1 ,3 ,4 ]
Park, Shin-Hyung [5 ,6 ]
Lee, Yoon Hee [1 ,3 ,4 ]
Hong, Dae Gy [1 ,3 ]
Lee, Yoon Soon [1 ,3 ]
机构：
[1] Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea
[2] Kyungpook Natl Univ Hosp, Dept Obstet & Gynecol, Daegu, South Korea
[3] Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu, South Korea
[4] Kyungpook Natl Univ, Sch Med, Mol Diagnost & Imaging Ctr, Daegu, South Korea
[5] Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea
[6] Kyungpook Natl Univ Hosp, Dept Radiat Oncol, Daegu, South Korea
来源：
ANTICANCER RESEARCH | 2020年 / 40卷 / 01期
关键词：
Locally advanced cervical cancer; post-treatment hematological parameters; prognosis; neutrophil-to-lymphocyte; concurrent chemoradiotherapy; NEUTROPHIL LYMPHOCYTE RATIO; TO-LYMPHOCYTE; INFLAMMATION; CARCINOMA;
D O I：
10.21873/anticanres.13973
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: We evaluated the clinical implications of pre- and post-treatment hematological parameters as prognostic factors in patients with locally advanced cervical cancer (LACC) who received definitive concurrent chemoradiotherapy (CCRT). Patients and Methods: We retrospectively analyzed 125 patients with LACC (FIGO stage IIB to IIIB) who received definitive CCRT. Clinical factors and hematological parameters, including neutrophil-to-lymphocyte ratio (NLR) were assessed pre- and post-CCRT. Univariate and multivariate analysis for disease-free survival (DFS) and overall survival (OS) were performed using clinicopathological and hematological parameters. Results: Disease recurred in 46 (36.8%) patients, and 24 patients (19.2%) died. On multivariate analysis, post-treatment NLR, Delta NLR (pre-treatment NLR/post-treatment NLR) and Delta PLR (platelet-to-lymphocyte ratio) (pre-treatment PLR/post-treatment PLR) were significant prognostic factors
引用
收藏
页码：451 / 458
页数：8
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