CITRUS FRUIT INTAKE DECREASES THE RISK OF INCIDENT TYPE 2 DIABETES: A SYSTEMATIC REVIEW AND META-ANALYSIS

Objective: Increasing total fruit consumption is often used in the management of typeII diabetes. However, so far we are not know the orange whether effective reduce the incidence of typeIIdiabetes so the target of this study was to review and conduct quantitative analyses of the results from expected cohort researches which assessed the correlation between the citrus ingestion and the risk of typeII diabetes. Materials and methods: The research team identified the pertinent studies by a systematical search in PubMed, Embase, Science Direct and Cochrane Library up to May 2017. Furthermore, the reseachers also used the random-effect model to combine the study-specific results and the subgroup analyses. Sensitivity analyses were also carried out. Researchers used the funnel plot of beg for estimating publication bias. Publication bias was estimated by using Begg's funnel plot. Results: This study selected a total 13 prospective studies that included 415462 participants from eight publications. The combined relative risk (RR) of type II diabetes for the highest versus the lowest category of the citrus fruit intake were 0.85 (95% CI, 0.78-0.92; p = 0.0001) for the incidence of all typeII diabetes events, and the correlation of subgroup analysis with sex, region, duration of follow-up, amount of cases and study quality was highly consistent with the overall data. For female subjects, there are exsit significant protective associations that between the citrus intake and the type II diabetes risk (RR, 0.83; 95% CI, 0.73-0.93; p = 0.000). The studies with follow-up were longer than 10 years (RR, 0.81; 95% CI, 0.73-0.89; p = 0.001). No publication bias was found. Conclusions: These results indicate that the consumption of citrusis inversely correlated with the risk of typeIIdiabetes, especially for female.