Analysis of racemic conjugates of purine with heterocyclic amines by chiral high-performance liquid chromatography

被引：6
|
作者：
Tumashov, A. A. [1 ,2 ]
Gruzdev, D. A. [1 ]
Vigorov, A. Yu. [1 ]
Musiyak, V. V. [1 ]
Chulakov, E. N. [1 ]
Levit, G. L. [1 ]
Krasnov, V. P. [1 ]
Charushin, V. N. [1 ,3 ]
机构：
[1] Russian Acad Sci, Ural Branch, I Ya Postovsky Inst Organ Synth, 22-20 Ul S Kovalevskoi, Ekaterinburg 620990, Russia
[2] Ural Fed Univ, Inst Nat Sci & Math, 19 Ul Mira, Ekaterinburg 620002, Russia
[3] Ural Fed Univ, Inst Chem Engn, 19 Ul Mira, Ekaterinburg 620002, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2018年 / 67卷 / 09期
基金：
俄罗斯科学基金会;
关键词：
purines; conjugates; heterocyclic amines; enantiomers; high-performance liquid chromatography; chiral stationary phases; (S; S)-Whelk-O1; column; ANTIMYCOBACTERIAL ACTIVITY; ADENOSINE-DEAMINASE; ACIDS; N-(2-AMINOPURIN-6-YL); ENANTIOMERS; PURIN-6-YL; FRAGMENT; BEARING; EHNA;
D O I：
10.1007/s11172-018-2279-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reversed-phase HPLC on chiral stationary phases was used to study the influence of the structure of purine and 2-aminopurine conjugates with chiral heterocyclic amines on the retention times. The optimum conditions for separation of enantiomers were found. The best parameters of separation of stereoisomers of all the compounds examined were achieved on a (S,S)-Whelk-O1 column in weakly alkaline aqueous methanol systems.
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页码：1704 / 1709
页数：6
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