Synthesis of N-α-Protected Amino Acid-Derived Selenocarbamates Employing Isocyanates as Key Intermediates

被引：3

作者：

Sureshbabu, Vommina V. ^{[1
]}

Naik, Shankar A. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Peptide Res Lab, Bangalore 560001, Karnataka, India

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 18期

关键词：

LiAlHSeH; N-protected amino alkyl isocyanates; selenium; selenocarbamates; ACIDS/PEPTIDE-ACIDS; FACILE METHOD; SELENIUM; ORGANOSELENIUM; DISELENIDES; ISONITRILES; SELENOUREA; CONVERSION; PROTEINS; HYDRIDE;

D O I：

10.1080/00397910903318641

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple protocol for the synthesis of N-urethane-protected N-alkyl-Se-alkyl selenocarbamate derivatives of amino acids has been described. The reaction of N-urethane-protected amino alkyl isocyanates with selenating agent LiAlHSeH and subsequent coupling with an alkyl halide yielded the title compounds in good yield and purity. All the selenocarbamates obtained have been characterized by 1H NMR, 13C NMR, and mass spectral studies.

引用

页码：2676 / 2685

页数：10

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