An efficient preparative route to 7-ethyl-1H-furo[2,3-g]indazole

被引：4
|
作者：
Shimada, I [1 ]
Maeno, K [1 ]
Kimizuka, T [1 ]
Goto, S [1 ]
Takahashi, T [1 ]
Nakamura, A [1 ]
Miyafuji, A [1 ]
Tsukamoto, S [1 ]
Sakamoto, S [1 ]
机构：
[1] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
来源：
HETEROCYCLES | 2004年 / 62卷
关键词：
5-HT2C receptor agonist; YM348; dehydration; aromatization; multi-kilogram; synthesis;
D O I：
10.3987/COM-03-S(P)26
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new and efficient route to 7-ethyl-1H-furo[2,3-g]indazole (2) has been developed. Treatment of 4,5-dihydro-7-(1-hydroxyethyl)indazole (12) with hydrochloric acid in ethanol resulted in a concomitant dehydration and aromatization to afford the title compound in good yield.
引用
收藏
页码：807 / 813
页数：7
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